Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.62 |
| ▸ | GLA | P06280 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.50 |
| ▸ | HTR2C | P28335 | 2/20 | 0.47 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.46 |
| ▸ | ATF1 | P18846 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | VHL | P40337 | 1/20 | 0.42 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | EDNRA | P25101 | 1/20 | 0.41 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1896996 | 0.84 | ALDH1A1 (0.66) | ALDH1A1SMN1; SMN2GLAPKMEPHX2 | |
| SCHEMBL1430802 | 0.82 | ALDH1A1 (0.64) | ALDH1A1SMN1; SMN2GLAPKMEPHX2 | |
| SCHEMBL11775192 | 0.81 | ALDH1A1 (0.62) | ALDH1A1SMN1; SMN2GLAPKMEPHX2 | |
| SCHEMBL18236187 | 0.79 | ALDH1A1 (0.63) | ALDH1A1SMN1; SMN2GLAPKMEPHX2 | |
| SCHEMBL15000477 | 0.79 | ALDH1A1 (0.60) | ALDH1A1SMN1; SMN2GLAPKMEPHX2 | |
| SCHEMBL22885243 | 0.79 | ALDH1A1 (0.60) | ALDH1A1SMN1; SMN2GLAPKMEPHX2 | |
| SCHEMBL17833337 | 0.78 | ALDH1A1 (0.73) | ALDH1A1SMN1; SMN2GLAPKMEPHX2 | |
| SCHEMBL3526214 | 0.78 | ALDH1A1 (0.58) | ALDH1A1SMN1; SMN2GLAPKMEPHX2 | |
| SCHEMBL209226 | 0.77 | ALDH1A1 (0.71) | ALDH1A1SMN1; SMN2GLAPKMEPHX2 | |
| SCHEMBL6431541 | 0.77 | ALDH1A1 (1.00) | ALDH1A1SMN1; SMN2GLAPKMEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10399932-B2 | Inhibitors of indoleamine-2,3-dioxygenase for the treatment of cancer | BRISTOL-MYERS SQUIBB COMPANY (US) | 2019-09-03 | — | — | US | disclosed |
| US-20180079712-A1 | INHIBITORS OF INDOLEAMINE-2,3-DIOXYGENASE FOR THE TREATMENT OF CANCER | BRISTOL MYERS SQUIBB CO (US) | 2018-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10399932-B2 | Inhibitors of indoleamine-2,3-dioxygenase for the treatment of cancer | IDO1, IDO2, INMT | ALDH1A1 263/4885SMN1; SMN2 4521/4885GLA 1274/4885 |
| US-20180079712-A1 | INHIBITORS OF INDOLEAMINE-2,3-DIOXYGENASE FOR THE TREATMENT OF CANCER | IDO1, IDO2, INMT | ALDH1A1 263/4885SMN1; SMN2 4521/4885GLA 1274/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.