Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K11 | Q16584 | 2/20 | 0.52 |
| ▸ | MAP3K9 | P80192 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | GMNN | O75496 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | LCK | P06239 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24767896 | 0.90 | KDM4E (0.51) | MAP3K11MAP3K9KDM4EALDH1A1HPGD | |
| SCHEMBL17228831 | 0.87 | MAP3K11 (0.59) | MAP3K11MAP3K9KDM4EALDH1A1MEN1 | |
| SCHEMBL29506369 | 0.87 | MAP3K11 (0.59) | MAP3K11MAP3K9KDM4EALDH1A1MEN1 | |
| SCHEMBL30883881 | 0.87 | MAP3K11 (0.59) | MAP3K11MAP3K9KDM4EALDH1A1MEN1 | |
| SCHEMBL21155926 | 0.80 | MAP3K11 (0.43) | MAP3K11MAP3K9KDM4EALDH1A1HPGD | |
| SCHEMBL19991873 | 0.79 | MAP3K11 (0.56) | MAP3K11MAP3K9ALDH1A1MEN1POLB | |
| SCHEMBL19988566 | 0.77 | MAP3K11 (0.53) | MAP3K11MAP3K9KDM4ECDK4CCND1 | |
| SCHEMBL19974124 | 0.77 | MAP3K11 (0.53) | MAP3K11MAP3K9CDK4CCND1GABRA1 | |
| SCHEMBL18086412 | 0.77 | MAP3K11 (0.51) | MAP3K11MAP3K9KDM4EALDH1A1MEN1 | |
| SCHEMBL17465511 | 0.77 | MAP3K11 (0.51) | MAP3K11MAP3K9ALDH1A1MEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3512848-B1 | COMPOUNDS WITH CARBAZOLE STRUCTURES | MERCK PATENT GMBH (DE) | 2020-11-18 | — | — | EP | disclosed |
| US-20190214574-A1 | COMPOUNDS WITH CARBAZOLE STRUCTURES | MERCK PATENT GMBH (DE) | 2019-07-11 | — | — | US | disclosed |
| WO-2018050583-A1 | COMPOUNDS WITH CARBAZOLE STRUCTURES | MERCK PATENT GMBH (DE) | 2018-03-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190214574-A1 | COMPOUNDS WITH CARBAZOLE STRUCTURES | CYCS, CYP3A4, CYP2E1 | MAP3K11 1974/4885MAP3K9 1892/4885KDM4E 2638/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.