Sugi Predict

Sugi Predict / Compounds / SCHEMBL19989366

SCHEMBL19989366

SCHEMBL19989366

O=S(=O)(c1ccc(Br)c(Cl)c1)N1CCC[C@H]1CO

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PLAU P00749 1/20 0.56
▸ HTR7 P34969 4/20 0.52
▸ HTR1A P08908 2/20 0.52
▸ DRD2 P14416 2/20 0.52
▸ HTR1D P28221 2/20 0.52
▸ HTR1B P28222 2/20 0.52
▸ DRD3 P35462 2/20 0.52
▸ HTR1E P28566 1/20 0.52
▸ ADRA1B P35368 1/20 0.52
▸ LOX P28300 1/20 0.48
▸ BRD4 O60885 1/20 0.48
▸ BRD2 P25440 1/20 0.48
▸ TSHR P16473 3/20 0.48
▸ PSEN1 P49768 2/20 0.47
▸ PSEN2 P49810 2/20 0.47
▸ APH1B Q8WW43 2/20 0.47
▸ NCSTN Q92542 2/20 0.47
▸ APH1A Q96BI3 2/20 0.47
▸ PSENEN Q9NZ42 2/20 0.47
▸ MEN1 O00255 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19989367 1.00 PLAU (0.56) PLAUHTR7HTR1ADRD2HTR1D
SCHEMBL29859509 1.00 PLAU (0.56) PLAUHTR7HTR1ADRD2HTR1D
SCHEMBL19989210 0.85 LOX (0.51) PLAUHTR7HTR1ADRD2HTR1D
SCHEMBL19989318 0.85 LOX (0.51) PLAUHTR7HTR1ADRD2HTR1D
SCHEMBL19989320 0.85 LOX (0.51) PLAUHTR7HTR1ADRD2HTR1D
SCHEMBL1684459 0.81 BRD4 (0.57) PLAUHTR7HTR1ADRD2HTR1D
SCHEMBL1684457 0.81 BRD4 (0.57) PLAUHTR7HTR1ADRD2HTR1D
SCHEMBL2567042 0.78 PSEN1 (0.56) PLAULOXBRD4BRD2TSHR
SCHEMBL5250378 0.78 PSEN1 (0.75) PLAUHTR7BRD4BRD2TSHR
SCHEMBL19989567 0.77 CASP3 (0.44) PLAUHTR7HTR1ADRD2HTR1D

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109715608-B Indazole compounds for use in tendon and/or ligament injuries 诺华股份有限公司 2022-08-05 — — CN disclosed
EP-3515894-B1 INDAZOLE COMPOUNDS FOR USE IN TENDON AND/OR LIGAMENT INJURIES NOVARTIS AG (CH) 2021-04-07 — — EP disclosed
EP-3515894-A1 INDAZOLE COMPOUNDS FOR USE IN TENDON AND/OR LIGAMENT INJURIES Novartis AG (CH) 2019-07-31 — — EP disclosed
US-10112907-B2 Substituted indazoles for treating tendon and/or ligament injuries NOVARTIS AG (CH) 2018-10-30 — — US disclosed
US-20180086716-A1 Indazole Compounds for Use in Tendon and/or Ligament Injuries NOVARTIS INSTITUTE FOR FUNCTIONAL GENOMICS, INC., DBA THE GENOMICS INSTITUTE OF THE NOVARTIS RESEARCH FOUNDATION 2018-03-29 — — US disclosed
WO-2018055550-A1 INDAZOLE COMPOUNDS FOR USE IN TENDON AND/OR LIGAMENT INJURIES NOVARTIS AG (CH) 2018-03-29 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10112907-B2 Substituted indazoles for treating tendon and/or ligament injuries SLC10A2, MMP1, TNNI3 PLAU 2523/4885HTR7 1585/4885HTR1A 2832/4885
US-20180086716-A1 Indazole Compounds for Use in Tendon and/or Ligament Injuries MMP1, SLC10A2, TNNI3 PLAU 2224/4885HTR7 2110/4885HTR1A 3580/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.