Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 5/20 | 0.45 |
| ▸ | TSHR | P16473 | 4/20 | 0.45 |
| ▸ | TACR1 | P25103 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 7/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | MGLL | Q99685 | 4/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19975519 | 0.89 | CYP2D6 (0.51) | CYP2D6TSHRTACR1ALDH1A1USP2 | |
| SCHEMBL19992929 | 0.81 | CYP2D6 (0.45) | CYP2D6TSHRTACR1ALDH1A1USP2 | |
| SCHEMBL28304786 | 0.77 | CYP3A4 (0.47) | CYP2D6TSHRTACR1ALDH1A1USP2 | |
| SCHEMBL20793838 | 0.77 | MGLL (0.59) | MGLL | |
| SCHEMBL28304841 | 0.77 | CYP2D6 (0.42) | CYP2D6TSHRTACR1ALDH1A1USP2 | |
| SCHEMBL20151867 | 0.75 | TSHR (0.58) | CYP2D6TSHRTACR1ALDH1A1USP2 | |
| SCHEMBL20503443 | 0.75 | CYP2D6 (0.50) | CYP2D6TSHRTACR1ALDH1A1USP2 | |
| SCHEMBL20793596 | 0.75 | ALDH1A1 (0.43) | CYP2D6TSHRALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL20137044 | 0.74 | CYP2D6 (0.54) | CYP2D6TSHRTACR1ALDH1A1USP2 | |
| SCHEMBL19974289 | 0.74 | CYP2D6 (0.46) | CYP2D6TSHRTACR1ALDH1A1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3515897-B1 | PIPERAZINE CARBAMATES AS MODULATORS OF MAGL AND/OR ABHD6 AND THEIR USE | H LUNDBECK AS (DK) | 2021-08-18 | — | — | EP | disclosed |
| WO-2018053447-A1 | PIPERAZINE CARBAMATES AND METHODS OF MAKING AND USING SAME | ABIDE THERAPEUTICS, INC. (US) | 2018-03-22 | — | — | WO | disclosed |