Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 4/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.46 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.44 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.44 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.44 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.44 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.44 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.44 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.44 |
| ▸ | PIM1 | P11309 | 3/20 | 0.40 |
| ▸ | PIM3 | Q86V86 | 3/20 | 0.40 |
| ▸ | PIM2 | Q9P1W9 | 3/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31334775 | 1.00 | PARP1 (0.47) | PARP1ALOX5GRIN2DGRIN3BGRIN1 | |
| SCHEMBL19994372 | 0.95 | PARP1 (0.48) | PARP1ALOX5GRIN2DGRIN3BGRIN1 | |
| SCHEMBL29464219 | 0.95 | PARP1 (0.48) | PARP1ALOX5GRIN2DGRIN3BGRIN1 | |
| SCHEMBL25364537 | 0.82 | PARP1 (0.48) | PARP1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL31334907 | 0.77 | PARP1 (0.44) | PARP1PIM1PIM3PIM2CNR2 | |
| SCHEMBL19994396 | 0.77 | ALOX5 (0.40) | PARP1ALOX5GRIN2DGRIN3BGRIN1 | |
| SCHEMBL20687962 | 0.77 | PARP1 (0.49) | PARP1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL20502452 | 0.76 | ALOX5 (0.55) | PARP1ALOX5GRIN2DGRIN3BGRIN1 | |
| SCHEMBL30087931 | 0.76 | ALOX5 (0.55) | PARP1ALOX5GRIN2DGRIN3BGRIN1 | |
| SCHEMBL25360946 | 0.76 | PARP1 (0.44) | PARP1PIM1PIM3PIM2CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210246130-A1 | DUAL INHIBITORS OF PHOSPHATIDYLINOSITOL 3-KINASE DELTA & GAMMA | ASTRAZENECA AB (SE) | 2021-08-12 | — | — | US | disclosed |
| US-10961236-B2 | (S)-2-(1-cyclopropylethyl)-5-(4-methyl-2-((6-(2-oxopyrrolidin-1-yl)pyridin-2-yl)amino) thiazol-5-yl)-7-(methylsulfonyl)isoindolin-1-one as a phosphatidylinositol 3-kinase inhibitor | ASTRAZENECA AB (SE) | 2021-03-30 | — | — | US | disclosed |
| US-20200308164-A1 | 5-[2-(PYRIDIN-2-YLAMINO)-1,3-THIAZOL-5-YL]-2,3-DIHYDRO-1 H-ISOINDOL-1 -ONE DERIVATIVES AND THEIR USE AS DUAL INHIBITORS OF PHOSPHATIDYLINOSITOL 3-KINASE DELTA & GAMMA | ASTRAZENECA AB (SE) | 2020-10-01 | — | — | US | disclosed |
| EP-3515910-B1 | 5-[2-(PYRIDIN-2-YLAMINO)-1,3-THIAZOL-5-YL]-2,3-DIHYDRO-1H-ISOINDOL-1-ONE DERIVATIVES AND THEIR USE AS DUAL INHIBITORS OF PHOSPHATIDYLINOSITOL 3-KINASE DELTA & GAMMA | ASTRAZENECA AB (SE) | 2020-07-15 | — | — | EP | disclosed |
| EP-3515910-A1 | 5-[2-(PYRIDIN-2-YLAMINO)-1,3-THIAZOL-5-YL]-2,3-DIHYDRO-1 H-ISOINDOL-1 -ONE DERIVATIVES AND THEIR USE AS DUAL INHIBITORS OF PHOSPHATIDYLINOSITOL 3-KINASE DELTA&GAMMA | Astrazeneca AB (SE) | 2019-07-31 | — | — | EP | disclosed |
| WO-2018055040-A1 | 5-[2-(PYRIDIN-2-YLAMINO)-1,3-THIAZOL-5-YL]-2,3-DIHYDRO-1 H-ISOINDOL-1 -ONE DERIVATIVES AND THEIR USE AS DUAL INHIBITORS OF PHOSPHATIDYLINOSITOL 3-KINASE DELTA & GAMMA | ASTRAZENECA AB (SE) | 2018-03-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200308164-A1 | 5-[2-(PYRIDIN-2-YLAMINO)-1,3-THIAZOL-5-YL]-2,3-DIHYDRO-1 H-ISOINDOL-1 -ONE DERIVATIVES AND THEIR USE AS DUAL INHIBITORS OF PHOSPHATIDYLINOSITOL 3-KINASE DELTA & GAMMA | PIK3CD, PIK3CG, PDPK1 | PARP1 1325/4885ALOX5 2551/4885GRIN2D 1917/4885 |
| US-10961236-B2 | (S)-2-(1-cyclopropylethyl)-5-(4-methyl-2-((6-(2-oxopyrrolidin-1-yl)pyridin-2-yl)amino) thiazol-5-yl)-7-(methylsulfonyl)isoindolin-1-one as a phosphatidylinositol 3-kinase inhibitor | PIK3CD, PIK3CB, PIK3CA | PARP1 1151/4885ALOX5 4091/4885GRIN2D 1205/4885 |
| US-20210246130-A1 | DUAL INHIBITORS OF PHOSPHATIDYLINOSITOL 3-KINASE DELTA & GAMMA | PIK3CD, PIK3CG, PRKCG | PARP1 1189/4885ALOX5 3158/4885GRIN2D 2015/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.