Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 6/20 | 0.55 |
| ▸ | PIM1 | P11309 | 1/20 | 0.45 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.45 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.45 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.43 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.41 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.40 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.40 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.40 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.40 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.40 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.35 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30087931 | 1.00 | ALOX5 (0.55) | ALOX5PIM1PIM3PIM2MAP4K1 | |
| SCHEMBL2193369 | 0.90 | ALOX5 (0.61) | ALOX5PIM1PIM3PIM2MAP4K1 | |
| SCHEMBL30712348 | 0.90 | ALOX5 (0.61) | ALOX5PIM1PIM3PIM2MAP4K1 | |
| SCHEMBL19994372 | 0.78 | PARP1 (0.48) | ALOX5PIM1PIM3PIM2MAP4K1 | |
| SCHEMBL29464219 | 0.78 | PARP1 (0.48) | ALOX5PIM1PIM3PIM2MAP4K1 | |
| SCHEMBL31334775 | 0.76 | PARP1 (0.47) | ALOX5PIM1PIM3PIM2MAP4K1 | |
| SCHEMBL19994341 | 0.76 | PARP1 (0.47) | ALOX5PIM1PIM3PIM2MAP4K1 | |
| SCHEMBL31747300 | 0.75 | CRBN (0.59) | ALOX5GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL24265517 | 0.74 | ALOX5 (0.50) | ALOX5PIM1PIM3PIM2MAP3K5 | |
| SCHEMBL31334558 | 0.74 | ALOX5 (0.43) | ALOX5PIM1GRIN2DGRIN3BGRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11944606-B2 | Azaindoles as inhibitors of HPK1 | GENENTECH, INC. (US) | 2024-04-02 | — | — | US | disclosed |
| EP-3596075-B1 | AZAINDOLES AS INHIBITORS OF HPK1 | HOFFMANN LA ROCHE (CH) | 2023-10-11 | — | — | EP | disclosed |
| EP-3596075-B1 | AZAINDOLES AS INHIBITORS OF HPK1 | HOFFMANN LA ROCHE (CH) | 2023-10-11 | — | — | EP | disclosed |
| CN-110402248-B | Azaindoles as HPK1 inhibitors | 豪夫迈·罗氏有限公司 | 2023-01-06 | — | — | CN | disclosed |
| US-20210299110-A1 | AZAINDOLES AS INHIBITORS OF HPK1 | GENENTECH, INC. (US) | 2021-09-30 | — | — | US | disclosed |
| US-20210299110-A1 | AZAINDOLES AS INHIBITORS OF HPK1 | GENENTECH, INC. (US) | 2021-09-30 | — | — | US | disclosed |
| CN-113015526-A | Spirocyclic 2, 3-dihydro-7-azaindole compounds and uses thereof | 豪夫迈·罗氏有限公司 | 2021-06-22 | — | — | CN | disclosed |
| US-10952995-B2 | Azaindoles as inhibitors of HPK1 | GENENTECH, INC. (US) | 2021-03-23 | — | — | US | disclosed |
| US-10952995-B2 | Azaindoles as inhibitors of HPK1 | GENENTECH, INC. (US) | 2021-03-23 | — | — | US | disclosed |
| WO-2020061377-A1 | SPIROCYCLIC 2,3-DIHYDRO-7-AZAINDOLE COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2020-03-26 | — | — | WO | disclosed |
| WO-2018167147-A1 | AZAINDOLES AS INHIBITORS OF HPK1 | F. HOFFMANN-LA ROCHE AG (CH) | 2018-09-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10952995-B2 | Azaindoles as inhibitors of HPK1 | HIPK1, HIPK2, PPIP5K2 | ALOX5 2558/4885PIM1 3102/4885PIM3 2938/4885 |
| US-11944606-B2 | Azaindoles as inhibitors of HPK1 | HIPK1, HIPK2, PPIP5K2 | ALOX5 2558/4885PIM1 3102/4885PIM3 2938/4885 |
| US-20210299110-A1 | AZAINDOLES AS INHIBITORS OF HPK1 | HIPK1, HIPK2, PPIP5K2 | ALOX5 2558/4885PIM1 3102/4885PIM3 2938/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.