Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.41 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.41 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.41 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.41 |
| ▸ | PARG | Q86W56 | 1/20 | 0.41 |
| ▸ | PLAU | P00749 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21407130 | 0.92 | KMT2A (0.45) | LMNAMAPK1SMN1; SMN2POLBTP53 | |
| SCHEMBL19994965 | 0.88 | KMT2A (0.51) | LMNAMAPK1SMN1; SMN2POLBTP53 | |
| SCHEMBL19994884 | 0.86 | SMN1; SMN2 (0.41) | LMNAMAPK1SMN1; SMN2POLBTP53 | |
| SCHEMBL19994928 | 0.84 | KMT2A (0.49) | LMNAMAPK1SMN1; SMN2POLBTP53 | |
| SCHEMBL21407132 | 0.84 | KMT2A (0.49) | LMNAMAPK1SMN1; SMN2POLBTP53 | |
| SCHEMBL29498518 | 0.84 | KMT2A (0.49) | LMNAMAPK1SMN1; SMN2POLBTP53 | |
| SCHEMBL19995179 | 0.84 | KMT2A (0.49) | LMNAMAPK1SMN1; SMN2POLBTP53 | |
| SCHEMBL21407131 | 0.83 | KMT2A (0.62) | LMNAMAPK1SMN1; SMN2POLBTP53 | |
| SCHEMBL29498527 | 0.81 | ALDH1A1 (0.55) | LMNAMAPK1SMN1; SMN2POLBTP53 | |
| SCHEMBL19994862 | 0.81 | ALDH1A1 (0.55) | LMNAMAPK1SMN1; SMN2POLBTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3515913-B1 | AZA-INDAZOLE COMPOUNDS FOR USE IN TENDON AND/OR LIGAMENT INJURIES | NOVARTIS AG (CH) | 2022-05-11 | — | — | EP | disclosed |
| US-11203595-B2 | Aza-indazole compounds for use in tendon and/or ligament injuries | NOVARTIS AG (CH) | 2021-12-21 | — | — | US | disclosed |
| US-20210188842-A1 | AZA-INDAZOLE COMPOUNDS FOR USE IN TENDON AND/OR LIGAMENT INJURIES | NOVARTIS AG (CH) | 2021-06-24 | — | — | US | disclosed |
| US-10766894-B2 | Aza-indazole compounds for use in tendon and/or ligament injuries | NOVARTIS AG (CH) | 2020-09-08 | — | — | US | disclosed |
| US-20190300522-A1 | AZA-INDAZOLE COMPOUNDS FOR USE IN TENDON AND/OR LIGAMENT INJURIES | NOVARTIS INSTITUTE FOR FUNCTIONAL GENOMICS, INC. | 2019-10-03 | — | — | US | disclosed |
| EP-3515913-A1 | AZA-INDAZOLE COMPOUNDS FOR USE IN TENDON AND/OR LIGAMENT INJURIES | Novartis AG (CH) | 2019-07-31 | — | — | EP | disclosed |
| WO-2018055551-A1 | AZA-INDAZOLE COMPOUNDS FOR USE IN TENDON AND/OR LIGAMENT INJURIES | NOVARTIS AG (CH) | 2018-03-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10766894-B2 | Aza-indazole compounds for use in tendon and/or ligament injuries | MMP1, TIMP3, ALPI | LMNA 1201/4885MAPK1 1575/4885SMN1; SMN2 1935/4885 |
| US-20190300522-A1 | AZA-INDAZOLE COMPOUNDS FOR USE IN TENDON AND/OR LIGAMENT INJURIES | MMP1, TIMP3, ALPI | LMNA 1201/4885MAPK1 1575/4885SMN1; SMN2 1935/4885 |
| US-20210188842-A1 | AZA-INDAZOLE COMPOUNDS FOR USE IN TENDON AND/OR LIGAMENT INJURIES | MMP1, ALPI, TIMP3 | LMNA 1053/4885MAPK1 1614/4885SMN1; SMN2 1763/4885 |
| US-11203595-B2 | Aza-indazole compounds for use in tendon and/or ligament injuries | MMP1, ALPI, TIMP3 | LMNA 1053/4885MAPK1 1614/4885SMN1; SMN2 1763/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.