Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 1/20 | 0.33 |
| ▸ | IL1B | P01584 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21407135 | 1.00 | TNF (0.33) | TNFIL1BHSD11B1 | |
| SCHEMBL19766546 | 0.77 | HSD11B1 (0.33) | TNFIL1BHSD11B1 | |
| SCHEMBL22482082 | 0.74 | ATM (0.37) | TNFIL1BHSD11B1 | |
| SCHEMBL22482090 | 0.74 | ATM (0.37) | TNFIL1BHSD11B1 | |
| SCHEMBL22887047 | 0.74 | HSD11B1 (0.35) | HSD11B1 | |
| SCHEMBL21948554 | 0.74 | HSD11B1 (0.35) | HSD11B1 | |
| SCHEMBL20727450 | 0.74 | HSD11B1 (0.35) | HSD11B1 | |
| SCHEMBL27310041 | 0.73 | HSD11B1 (0.37) | TNFIL1BHSD11B1 | |
| SCHEMBL12108434 | 0.72 | HSD11B1 (0.34) | HSD11B1 | |
| SCHEMBL23573544 | 0.71 | TNF (0.32) | TNFIL1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3515913-B1 | AZA-INDAZOLE COMPOUNDS FOR USE IN TENDON AND/OR LIGAMENT INJURIES | NOVARTIS AG (CH) | 2022-05-11 | — | — | EP | disclosed |
| US-11203595-B2 | Aza-indazole compounds for use in tendon and/or ligament injuries | NOVARTIS AG (CH) | 2021-12-21 | — | — | US | disclosed |
| US-20210188842-A1 | AZA-INDAZOLE COMPOUNDS FOR USE IN TENDON AND/OR LIGAMENT INJURIES | NOVARTIS AG (CH) | 2021-06-24 | — | — | US | disclosed |
| US-10766894-B2 | Aza-indazole compounds for use in tendon and/or ligament injuries | NOVARTIS AG (CH) | 2020-09-08 | — | — | US | disclosed |
| US-20190300522-A1 | AZA-INDAZOLE COMPOUNDS FOR USE IN TENDON AND/OR LIGAMENT INJURIES | NOVARTIS INSTITUTE FOR FUNCTIONAL GENOMICS, INC. | 2019-10-03 | — | — | US | disclosed |
| EP-3515913-A1 | AZA-INDAZOLE COMPOUNDS FOR USE IN TENDON AND/OR LIGAMENT INJURIES | Novartis AG (CH) | 2019-07-31 | — | — | EP | disclosed |
| WO-2018055551-A1 | AZA-INDAZOLE COMPOUNDS FOR USE IN TENDON AND/OR LIGAMENT INJURIES | NOVARTIS AG (CH) | 2018-03-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10766894-B2 | Aza-indazole compounds for use in tendon and/or ligament injuries | MMP1, TIMP3, ALPI | TNF 1336/4885IL1B 314/4885HSD11B1 220/4885 |
| US-20190300522-A1 | AZA-INDAZOLE COMPOUNDS FOR USE IN TENDON AND/OR LIGAMENT INJURIES | MMP1, TIMP3, ALPI | TNF 1336/4885IL1B 314/4885HSD11B1 220/4885 |
| US-20210188842-A1 | AZA-INDAZOLE COMPOUNDS FOR USE IN TENDON AND/OR LIGAMENT INJURIES | MMP1, ALPI, TIMP3 | TNF 1242/4885IL1B 303/4885HSD11B1 221/4885 |
| US-11203595-B2 | Aza-indazole compounds for use in tendon and/or ligament injuries | MMP1, ALPI, TIMP3 | TNF 1242/4885IL1B 303/4885HSD11B1 221/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.