Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 3/20 | 0.54 |
| ▸ | FPR1 | P21462 | 2/20 | 0.49 |
| ▸ | MAOA | P21397 | 3/20 | 0.44 |
| ▸ | KDM1A | O60341 | 3/20 | 0.44 |
| ▸ | MAOB | P27338 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.39 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8486986 | 0.85 | REN (0.52) | RENFPR1MAOAKDM1AMAOB | |
| SCHEMBL14432358 | 0.85 | REN (0.52) | RENFPR1MAOAKDM1AMAOB | |
| SCHEMBL28103960 | 0.85 | REN (0.52) | RENFPR1MAOAKDM1AMAOB | |
| SCHEMBL19994133 | 0.79 | FPR1 (0.51) | FPR1 | |
| Hydrochloric Acid SCHEMBL8640129 | 0.78 | MAPT (0.51) | RENFPR1MAOAKDM1AMAOB | |
| SCHEMBL14256183 | 0.77 | REN (0.53) | RENFPR1ALDH1A1SMN1; SMN2 | |
| SCHEMBL14256225 | 0.77 | REN (0.45) | RENFPR1 | |
| SCHEMBL17474540 | 0.77 | FPR1 (0.52) | RENFPR1MAOAKDM1AMAOB | |
| SCHEMBL8448724 | 0.76 | REN (0.56) | RENFPR1MAOAKDM1AMAOB | |
| SCHEMBL16874609 | 0.76 | REN (0.52) | RENFPR1MAOAKDM1AMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3515902-A1 | 6-MEMBERED CYCLIC AMINES OR LACTAMES SUBSTITUTED WITH UREA AND PHENYL | Grünenthal GmbH (DE) | 2019-07-31 | — | — | EP | disclosed |
| WO-2018054549-A1 | 6-MEMBERED CYCLIC AMINES OR LACTAMES SUBSTITUTED WITH UREA AND PHENYL | Grünenthal GmbH (DE) | 2018-03-29 | — | — | WO | disclosed |