Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 10/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.39 |
| ▸ | F2 | P00734 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | SRD5A2 | P31213 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20305039 | 0.73 | ALDH1A1 (0.46) | TSHRALDH1A1SRD5A2HPGDMAPT | |
| SCHEMBL25268554 | 0.68 | SRD5A2 (0.44) | ALDH1A1SRD5A2MAPT | |
| SCHEMBL6194728 | 0.67 | OGA (0.50) | TSHRALDH1A1SRD5A2HPGDMAPT | |
| SCHEMBL22468405 | 0.67 | MEN1 (0.31) | KMT2AMEN1MAPTTAAR1 | |
| SCHEMBL22468396 | 0.67 | MEN1 (0.31) | KMT2AMEN1MAPTTAAR1 | |
| SCHEMBL28182671 | 0.65 | LMNA (0.61) | KMT2ATSHRF2LMNAALDH1A1 | |
| SCHEMBL11229507 | 0.65 | LMNA (0.61) | KMT2ATSHRF2LMNAALDH1A1 | |
| SCHEMBL322928 | 0.65 | NOTUM (0.70) | KMT2AMEN1TSHRLMNAALDH1A1 | |
| SCHEMBL11236018 | 0.65 | KMT2A (0.50) | KMT2AMEN1TSHRCASP3SENP7 | |
| SCHEMBL176857 | 0.65 | F2 (0.45) | KMT2AMEN1TSHRCASP3SENP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3515888-A1 | TRPV4 ANTAGONISTS | GlaxoSmithKline Intellectual Property (No. 2) Limited (GB) | 2019-07-31 | — | — | EP | disclosed |
| WO-2018055526-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2018-03-29 | — | — | WO | disclosed |