Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.68 |
| ▸ | MEN1 | O00255 | 2/20 | 0.68 |
| ▸ | MAPT | P10636 | 1/20 | 0.68 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.65 |
| ▸ | NPC1 | O15118 | 1/20 | 0.65 |
| ▸ | TP53 | P04637 | 1/20 | 0.65 |
| ▸ | RAB9A | P51151 | 1/20 | 0.65 |
| ▸ | TMPRSS2 | O15393 | 1/20 | 0.59 |
| ▸ | HTR1A | P08908 | 1/20 | 0.59 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.59 |
| ▸ | MAOA | P21397 | 1/20 | 0.59 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 4/20 | 0.58 |
| ▸ | LMNA | P02545 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | HTT | P42858 | 2/20 | 0.58 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL21496871 | 0.98 | NOTUM (0.68) | NOTUMKMT2AMEN1MAPTTAAR1 | |
| Hydrochloric Acid SCHEMBL28278641 | 0.96 | NOTUM (0.66) | NOTUMKMT2AMEN1MAPTTAAR1 | |
| SCHEMBL2124966 | 0.90 | NOTUM (0.60) | NOTUMKMT2AMEN1MAPTTAAR1 | |
| SCHEMBL23114040 | 0.89 | RIPK1 (0.66) | NOTUMKMT2AMEN1MAPTTAAR1 | |
| SCHEMBL27901981 | 0.86 | NOTUM (0.72) | NOTUMKMT2AMEN1MAPTTAAR1 | |
| SCHEMBL2533362 | 0.85 | NOTUM (0.64) | NOTUMKMT2AMEN1MAPTTAAR1 | |
| SCHEMBL29758685 | 0.85 | NOTUM (0.64) | NOTUMKMT2AMEN1MAPTTAAR1 | |
| SCHEMBL28253826 | 0.84 | ALDH1A1 (0.59) | NOTUMKMT2AMEN1MAPTTAAR1 | |
| SCHEMBL4290743 | 0.84 | NOTUM (0.70) | NOTUMKMT2AMEN1MAPTTAAR1 | |
| SCHEMBL4279383 | 0.83 | HPGD (0.73) | NOTUMKMT2AMEN1MAPTTAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 781 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4301736-B1 | MACROCYCLIC COMPOUNDS AS PROTEASOME SUBUNIT BETA TYPE-5 INHIBITORS | LEAD DISCOVERY CENTER GMBH (DE) | 2025-10-08 | — | — | EP | claimed |
| US-20240415819-A1 | MACROCYCLIC COMPOUNDS AS PROTEASOME SUBUNIT BETA TYPE-5 INHIBITORS | QLi5 Therapeutics AG (DE) | 2024-12-19 | — | — | US | claimed |
| CN-117024511-A | Novel coronavirus-resistant peptidomimetic compound and preparation method thereof | 烟台大学 | 2023-11-10 | — | — | CN | claimed |
| EP-4155296-A1 | MACROCYCLIC COMPOUNDS AS PROTEASOME SUBUNIT BETA TYPE-5 INHIBITORS | Lead Discovery Center GmbH (DE) | 2023-03-29 | — | — | EP | claimed |
| WO-2022104001-A1 | EXPANDED PROTEIN LIBRARIES AND USES THEREOF | BRISTOL-MYERS SQUIBB COMPANY (US) | 2022-05-19 | — | — | WO | claimed |
| CN-114364658-A | Preparation method and composition of levo-praziquantel and chiral intermediate thereof | 苏州同力生物医药有限公司 | 2022-04-15 | — | — | CN | claimed |
| EP-3956348-A1 | PEPTIDE-BASED NON-PROTEINACEOUS CARGO DELIVERY | Feldan Bio Inc. (CA) | 2022-02-23 | — | — | EP | claimed |
| WO-2020210916-A1 | PEPTIDE-BASED NON-PROTEINACEOUS CARGO DELIVERY | FELDAN BIO INC. (CA) | 2020-10-22 | — | — | WO | claimed |
| US-20190070149-A1 | PRIMARY AMINES AND DERIVATIVES THEREOF AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. | 2019-03-07 | — | — | US | claimed |
| CN-107778230-A | A kind of synthetic method of tetrahydro isoquinoline derivative | 湖南华腾制药有限公司 | 2018-03-09 | — | — | CN | claimed |
| WO-1997031940-A1 | ISOQUINOLINES USEFUL AS ANALGESICS | ASTRA AKTIEBOLAG (SE) | 1997-09-04 | — | — | WO | claimed |
| WO-1997023484-A1 | NEW COMPOUNDS | ASTRA AKTIEBOLAG (SE) | 1997-07-03 | — | — | WO | claimed |
| WO-1997017050-A2 | AN IMPROVED METHOD FOR PREPARATION OF SUBSTITUTED TETRAHYDROISOQUINOLINES | MONSANTO COMPANY (US) | 1997-05-15 | — | — | WO | claimed |
| US-5618792-A | USEFUL FOR TREATING ACUTE RESPIRATORY DISEASES, AND MYOCARDIAL ISHCEMIA-REPERFUSION INJURY | CORTECH, INC. (US) | 1997-04-08 | — | — | US | claimed |
| WO-1996040742-A1 | PEPTIDYL HETEROCYCLES USEFUL IN THE TREATMENT OF THROMBIN RELATEDDISORDERS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1996-12-19 | — | — | WO | claimed |
| WO-1996040741-A1 | PEPTIDYL HETEROCYCLES USEFUL IN THE TREATMENT OF THROMBIN RELATED DISORDERS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1996-12-19 | — | — | WO | claimed |
| WO-1996040748-A1 | PEPTIDYL HETEROCYCLES USEFUL IN THE TREATMENT OF THROMBIN RELATED DISORDERS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1996-12-19 | — | — | WO | claimed |
| EP-0714909-A1 | Composition for prophylaxis or treatment of pulmonary circulatory diseases | Takeda Chemical Industries, Ltd. (JP) | 1996-06-05 | — | — | EP | claimed |
| US-5523308-A | SERINE PROTEASES INHIBITORS; ORAL ANTICOAGULANTS; CHEMICAL INTERMEDIATES; DIPEPTIDES | ORTHO PHARMACEUTICAL CORPORATION | 1996-06-04 | — | — | US | claimed |
| CN-1068333-A | Has hydrazine analog derivative of pharmacologically active and preparation method thereof | CIBA GEIGY AG (CH) | 1993-01-27 | — | — | CN | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190070149-A1 | PRIMARY AMINES AND DERIVATIVES THEREOF AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | HTR5A, HTR2A, HTR1A | NOTUM 2411/4885KMT2A 799/4885MEN1 3346/4885 |
| US-20240415819-A1 | MACROCYCLIC COMPOUNDS AS PROTEASOME SUBUNIT BETA TYPE-5 INHIBITORS | PSMB5, PSMA5, PSMB1 | NOTUM 1110/4885KMT2A 3101/4885MEN1 1276/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.