Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 2/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.34 |
| ▸ | RELA | Q04206 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | CASP3 | P42574 | 1/20 | 0.34 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.34 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.34 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 4/20 | 0.34 |
| ▸ | EED | O75530 | 1/20 | 0.33 |
| ▸ | RBBP4 | Q09028 | 1/20 | 0.33 |
| ▸ | SUZ12 | Q15022 | 1/20 | 0.33 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.33 |
| ▸ | AEBP2 | Q6ZN18 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19995475 | 0.86 | PIK3CD (0.40) | PIK3CDNPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL18096385 | 0.82 | CRBN (0.42) | PIK3CDGPR119MAPTNR1H2CTSD | |
| SCHEMBL18096372 | 0.80 | RAB9A (0.44) | GPR119NPC1RAB9AMAPTL3MBTL1 | |
| SCHEMBL19995492 | 0.77 | SMN1; SMN2 (0.41) | PIK3CDNPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL26125514 | 0.72 | PANK3 (0.40) | PIK3CDGPR119 | |
| SCHEMBL30546297 | 0.72 | PANK3 (0.40) | PIK3CDGPR119 | |
| SCHEMBL24700268 | 0.72 | USP30 (0.48) | PIK3CDGPR119NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL18096155 | 0.71 | MAP4K4 (0.42) | NR1H2CSNK2A1MAP4K4NR1H3 | |
| SCHEMBL19995494 | 0.69 | ATR (0.36) | SMN1; SMN2MAPTNR1H2CSNK2A1MAP4K4 | |
| SCHEMBL18096349 | 0.69 | MAP4K4 (0.36) | SMN1; SMN2MAPTNR1H2CSNK2A1MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018057588-A1 | FURO[3,2-B]PYRIDINE COMPOUNDS USEFUL AS INHIBITORS OF THE PAR-2 SIGNALING PATHWAY | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2018-03-29 | — | — | WO | disclosed |
| WO-2018057588-A1 | FURO[3,2-B]PYRIDINE COMPOUNDS USEFUL AS INHIBITORS OF THE PAR-2 SIGNALING PATHWAY | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2018-03-29 | — | — | WO | disclosed |