Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.38 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.38 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | CRHBP | P24387 | 2/20 | 0.34 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19995461 | 0.86 | PIK3CD (0.38) | PIK3CDNPC1RAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL19995492 | 0.81 | SMN1; SMN2 (0.41) | PIK3CDNPC1RAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL18096385 | 0.68 | CRBN (0.42) | PIK3CDMAPTKMT2AMEN1 | |
| SCHEMBL18096372 | 0.65 | RAB9A (0.44) | NPC1RAB9AL3MBTL1MAPTKDM4E | |
| SCHEMBL14686907 | 0.65 | PIK3C3 (0.42) | NPC1RAB9ASMN1; SMN2L3MBTL1MAPT | |
| SCHEMBL4770167 | 0.64 | GABRP (0.65) | NPC1RAB9ASMN1; SMN2L3MBTL1MAPT | |
| SCHEMBL21041119 | 0.64 | NNMT (0.69) | NPC1RAB9ASMN1; SMN2L3MBTL1MAPT | |
| SCHEMBL12500156 | 0.63 | NPC1 (0.57) | NPC1RAB9ASMN1; SMN2L3MBTL1MAPT | |
| SCHEMBL28105678 | 0.63 | NPC1 (0.47) | PIK3CDNPC1RAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL14687339 | 0.63 | NPC1 (0.44) | NPC1RAB9ASMN1; SMN2L3MBTL1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018057588-A1 | FURO[3,2-B]PYRIDINE COMPOUNDS USEFUL AS INHIBITORS OF THE PAR-2 SIGNALING PATHWAY | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2018-03-29 | — | — | WO | disclosed |