Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKD1 | Q15139 | 1/20 | 0.44 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | CSF1R | P07333 | 2/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.37 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.37 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.37 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.37 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.36 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.36 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.35 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1578875 | 0.87 | PRKD1 (0.44) | PRKD1PRKD2HDAC1PRKCQKDM4E | |
| SCHEMBL30686600 | 0.81 | PRKD1 (0.48) | PRKD1PRKD2HDAC1PRKCQKDM4E | |
| Hydrochloric Acid SCHEMBL28543430 | 0.80 | PRKD1 (0.48) | PRKD1PRKD2HDAC1PRKCQKDM4E | |
| Hydrochloric Acid SCHEMBL31368928 | 0.79 | PRKD1 (0.39) | PRKD1PRKD2HDAC1PRKCQKDM4E | |
| SCHEMBL31369004 | 0.78 | LATS1 (0.38) | PRKD1PRKD2HDAC1PRKCQKDM4E | |
| SCHEMBL31320165 | 0.75 | PTGER4 (0.44) | KDM4EKMT2AMEN1PIK3CAPIK3CB | |
| SCHEMBL20000452 | 0.75 | PRKCQ (0.61) | PRKD1PRKD2HDAC1PRKCQKDM4E | |
| SCHEMBL30686532 | 0.75 | CHRNB2 (0.45) | HDAC1CSF1RFGFR1FGFR2FGFR3 | |
| SCHEMBL31368772 | 0.75 | CHRNB2 (0.45) | HDAC1CSF1RFGFR1FGFR2FGFR3 | |
| SCHEMBL19367477 | 0.75 | PIK3CA (0.60) | KMT2AMEN1AURKAPIK3CAPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018057588-A1 | FURO[3,2-B]PYRIDINE COMPOUNDS USEFUL AS INHIBITORS OF THE PAR-2 SIGNALING PATHWAY | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2018-03-29 | — | — | WO | disclosed |