Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS5 | Q9UNA0 | 11/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | MMP2 | P08253 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19996698 | 0.89 | ADAMTS5 (0.69) | ADAMTS5MMP2 | |
| SCHEMBL23901410 | 0.85 | ADAMTS5 (0.67) | ADAMTS5KMT2AMEN1MAPTLMNA | |
| SCHEMBL23901405 | 0.83 | ADAMTS5 (0.71) | ADAMTS5MMP2 | |
| SCHEMBL17871418 | 0.82 | ADAMTS5 (0.84) | ADAMTS5MMP2 | |
| SCHEMBL23901420 | 0.82 | ADAMTS5 (0.71) | ADAMTS5MMP2 | |
| SCHEMBL23901404 | 0.79 | ADAMTS5 (0.71) | ADAMTS5MMP2 | |
| SCHEMBL23901205 | 0.79 | ADAMTS5 (0.70) | ADAMTS5KMT2AMEN1MMP2 | |
| SCHEMBL19996688 | 0.78 | ADAMTS5 (0.71) | ADAMTS5MMP2 | |
| SCHEMBL22892257 | 0.78 | ADAMTS5 (0.56) | ADAMTS5MMP2 | |
| SCHEMBL23901339 | 0.77 | ADAMTS5 (0.72) | ADAMTS5MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9926281-B2 | 5-[(piperazin-1-yl)-3-oxo-propyl]-imidazolidine-2,4-dione derivatives as ADAMTS inhibitors for the treatment of osteoarthritis | GALAPAGOS NV (BE) | 2018-03-27 | — | — | US | disclosed |