Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS5 | Q9UNA0 | 19/20 | 0.69 |
| ▸ | MMP1 | P03956 | 1/20 | 0.57 |
| ▸ | ADAM17 | P78536 | 3/20 | 0.53 |
| ▸ | AR | P10275 | 1/20 | 0.51 |
| ▸ | MMP2 | P08253 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19996668 | 0.89 | ADAMTS5 (0.59) | ADAMTS5MMP2 | |
| SCHEMBL23901404 | 0.86 | ADAMTS5 (0.71) | ADAMTS5MMP1ADAM17MMP2 | |
| SCHEMBL23901405 | 0.86 | ADAMTS5 (0.71) | ADAMTS5ADAM17MMP2 | |
| SCHEMBL23901410 | 0.86 | ADAMTS5 (0.67) | ADAMTS5ADAM17MMP2 | |
| SCHEMBL23901408 | 0.85 | ADAMTS5 (0.71) | ADAMTS5MMP1ADAM17ARMMP2 | |
| SCHEMBL25948021 | 0.83 | ADAMTS5 (0.72) | ADAMTS5MMP1ADAM17AR | |
| SCHEMBL17871597 | 0.82 | ADAMTS5 (1.00) | ADAMTS5MMP1ADAM17MMP2 | |
| SCHEMBL23901205 | 0.80 | ADAMTS5 (0.70) | ADAMTS5ADAM17MMP2 | |
| SCHEMBL23901420 | 0.79 | ADAMTS5 (0.71) | ADAMTS5ADAM17MMP2 | |
| SCHEMBL22892257 | 0.79 | ADAMTS5 (0.56) | ADAMTS5MMP1ADAM17MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9926281-B2 | 5-[(piperazin-1-yl)-3-oxo-propyl]-imidazolidine-2,4-dione derivatives as ADAMTS inhibitors for the treatment of osteoarthritis | GALAPAGOS NV (BE) | 2018-03-27 | — | — | US | disclosed |