Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS5 | Q9UNA0 | 20/20 | 0.71 |
| ▸ | MMP2 | P08253 | 3/20 | 0.61 |
| ▸ | ADAM17 | P78536 | 8/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23901404 | 0.89 | ADAMTS5 (0.71) | ADAMTS5MMP2ADAM17 | |
| SCHEMBL19996698 | 0.86 | ADAMTS5 (0.69) | ADAMTS5MMP2ADAM17 | |
| SCHEMBL23901420 | 0.83 | ADAMTS5 (0.71) | ADAMTS5MMP2ADAM17 | |
| SCHEMBL19996668 | 0.83 | ADAMTS5 (0.59) | ADAMTS5MMP2 | |
| SCHEMBL17871129 | 0.83 | ADAMTS5 (1.00) | ADAMTS5MMP2ADAM17 | |
| SCHEMBL19996688 | 0.80 | ADAMTS5 (0.71) | ADAMTS5MMP2ADAM17 | |
| SCHEMBL23901410 | 0.79 | ADAMTS5 (0.67) | ADAMTS5MMP2ADAM17 | |
| SCHEMBL22892257 | 0.77 | ADAMTS5 (0.56) | ADAMTS5MMP2ADAM17 | |
| SCHEMBL19701782 | 0.77 | ADAMTS5 (0.61) | ADAMTS5MMP2ADAM17 | |
| SCHEMBL23901205 | 0.77 | ADAMTS5 (0.70) | ADAMTS5MMP2ADAM17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210309614-A1 | 5-[(PIPERAZIN-1-YL)-3-OXO-PROPYL]-IMIDAZOLIDINE-2,4-DIONE DERIVATIVES AS ADAMTS INHIBITORS FOR THE TREATMENT OF OSTEOARTHRITIS | GALAPAGOS NV (BE) | 2021-10-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210309614-A1 | 5-[(PIPERAZIN-1-YL)-3-OXO-PROPYL]-IMIDAZOLIDINE-2,4-DIONE DERIVATIVES AS ADAMTS INHIBITORS FOR THE TREATMENT OF OSTEOARTHRITIS | ADAMTS1, ADAMTS5, ADAMTS7 | ADAMTS5 2/4885MMP2 53/4885ADAM17 8/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.