Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.74 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.74 |
| ▸ | LMNA | P02545 | 2/20 | 0.67 |
| ▸ | THRB | P10828 | 1/20 | 0.67 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.67 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.65 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.65 |
| ▸ | GAA | P10253 | 4/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.63 |
| ▸ | APP | P05067 | 1/20 | 0.63 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.63 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.63 |
| ▸ | HTT | P42858 | 1/20 | 0.63 |
| ▸ | ALPL | P05186 | 1/20 | 0.63 |
| ▸ | ALPI | P09923 | 1/20 | 0.63 |
| ▸ | ALPG | P10696 | 1/20 | 0.63 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
| ▸ | F7 | P08709 | 1/20 | 0.61 |
| ▸ | F3 | P13726 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29011921 | 0.94 | GAA (0.71) | HDAC1HDAC6LMNATHRBHIF1A | |
| SCHEMBL5793445 | 0.90 | HDAC1 (0.67) | HDAC1HDAC6LMNATHRBHIF1A | |
| SCHEMBL9118071 | 0.88 | HDAC1 (0.65) | HDAC1HDAC6LMNATHRBHIF1A | |
| SCHEMBL2488253 | 0.88 | HDAC1 (0.65) | HDAC1HDAC6LMNATHRBHIF1A | |
| Nicotinyl Methylamide SCHEMBL30664356 | 0.88 | HDAC1 (0.69) | HDAC1HDAC6LMNATHRBHIF1A | |
| Nicotinyl Methylamide SCHEMBL129458 | 0.88 | HDAC1 (0.69) | HDAC1HDAC6LMNATHRBHIF1A | |
| Nicotinyl Methylamide SCHEMBL28560459 | 0.88 | HDAC1 (0.69) | HDAC1HDAC6LMNATHRBHIF1A | |
| SCHEMBL5361880 | 0.87 | HDAC1 (0.74) | HDAC1HDAC6LMNATHRBHIF1A | |
| SCHEMBL28712350 | 0.87 | ALDH1A1 (0.66) | HDAC1HDAC6LMNATHRBHIF1A | |
| Nicotinyl Methylamide SCHEMBL9275531 | 0.86 | HDAC1 (0.67) | HDAC1HDAC6LMNATHRBHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7964613-B2 | (S)-3-amino-1-(4-bromo-5-isoquinolinesulfonyl)pyrrolidine; inhibits phosphorylation of myosin regulatory light chain; for spinal canal stenosis, spinal cord injury, rheumatoid arthritis, multiple sclerosis; Rho kinase inhibitors | ASAHI KASEI PHARMA CORPORATION (JP) | 2011-06-21 | — | — | US | disclosed |
| EP-2130828-A1 | SULFONAMIDE DERIVATIVE | Asahi Kasei Pharma Corporation (JP) | 2009-12-09 | — | — | EP | disclosed |
| US-20090048223-A1 | Sulfonamide compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-02-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090048223-A1 | Sulfonamide compound | ALK, AKT1, ARAF | HDAC1 989/4885HDAC6 1107/4885LMNA 2215/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.