Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELOVL1 | Q9BW60 | 2/20 | 0.61 |
| ▸ | HRH4 | Q9H3N8 | 6/20 | 0.49 |
| ▸ | ACACB | O00763 | 4/20 | 0.46 |
| ▸ | DRD1 | P21728 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | RELA | Q04206 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | CHKA | P35790 | 1/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL172123 | 0.86 | ACACB (0.48) | ELOVL1HRH4ACACB | |
| SCHEMBL19468728 | 0.86 | ELOVL1 (0.58) | ELOVL1HRH4ACACBDRD1MAPT | |
| SCHEMBL19468798 | 0.83 | ELOVL1 (0.55) | ELOVL1HRH4ACACBDRD1MAPT | |
| SCHEMBL15918793 | 0.82 | ELOVL1 (0.59) | ELOVL1HRH4ACACBDRD1 | |
| SCHEMBL19468840 | 0.75 | ELOVL1 (0.50) | ELOVL1HRH4ACACBCHKA | |
| SCHEMBL20000616 | 0.75 | ELOVL1 (0.56) | ELOVL1HRH4ACACBMAPTNPC1 | |
| SCHEMBL18176127 | 0.74 | ACACB (0.51) | ELOVL1HRH4ACACBDRD1CHKA | |
| SCHEMBL14530203 | 0.74 | ELOVL1 (0.69) | ELOVL1MAPTTP53KMT2ATSHR | |
| SCHEMBL13106499 | 0.74 | GRIN1 (0.58) | MAPTKMT2ASMN1; SMN2KCNH2HRH3 | |
| SCHEMBL4764176 | 0.74 | HRH3 (0.68) | MAPTNPC1TP53NFKB1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2997024-B1 | PYRROLIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | BOEHRINGER INGELHEIM INT (DE) | 2018-03-28 | — | — | EP | disclosed |