Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 5/20 | 0.46 |
| ▸ | GBA1 | P04062 | 2/20 | 0.43 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.42 |
| ▸ | DPP4 | P27487 | 2/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.40 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | SORD | Q00796 | 2/20 | 0.39 |
| ▸ | MAP3K12 | Q12852 | 2/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | UBE2T | Q9NPD8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8549105 | 0.81 | GBA1 (0.56) | GBA1CXCR4HRH3SORD | |
| SCHEMBL30635502 | 0.79 | GBA1 (0.55) | GBA1CXCR4HRH3SORD | |
| SCHEMBL27941842 | 0.79 | GBA1 (0.55) | GBA1CXCR4HRH3SORD | |
| SCHEMBL30637430 | 0.79 | SORD (0.47) | ACACBGBA1DPP4PDE10ASORD | |
| SCHEMBL30637363 | 0.77 | SORD (0.45) | ACACBGBA1EIF2AK4SORDMAP3K12 | |
| SCHEMBL26711595 | 0.76 | TRPV1 (0.42) | EIF2AK4PDE10AHRH3SORDMAP3K12 | |
| SCHEMBL20745960 | 0.73 | ACACB (0.41) | ACACBEIF2AK4SORDMAP3K12ROCK2 | |
| SCHEMBL30954035 | 0.72 | HRH3 (0.66) | HRH3SORDROCK2 | |
| SCHEMBL30954009 | 0.72 | TRPV1 (0.47) | PDE10AHRH3SORD | |
| SCHEMBL30693986 | 0.72 | HRH3 (0.43) | ACACBPDE10AHRH3SORDROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2997024-B1 | PYRROLIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | BOEHRINGER INGELHEIM INT (DE) | 2018-03-28 | — | — | EP | disclosed |