SCHEMBL2000120

SCHEMBL2000120

NNc1ccccc1Oc1ccccc1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.58
ADRA2C P18825 1/20 0.54
L3MBTL1 Q9Y468 4/20 0.49
GAA P10253 3/20 0.49
PKM P14618 2/20 0.49
POLB P06746 2/20 0.46
LMNA P02545 2/20 0.46
TDP1 Q9NUW8 1/20 0.46
LTA4H P09960 1/20 0.46
HRH1 P35367 1/20 0.46
CTNNB1 P35222 1/20 0.46
ATM Q13315 2/20 0.45
ALDH1A1 P00352 1/20 0.45
NPSR1 Q6W5P4 1/20 0.45
MAPK1 P28482 1/20 0.44
KMT2A Q03164 1/20 0.44
CA12 O43570 1/20 0.43
CA1 P00915 1/20 0.43
CA2 P00918 1/20 0.43
CA9 Q16790 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL4382625 0.98 TSHR (0.56) TSHRADRA2CL3MBTL1GAAPKM
SCHEMBL30490056 0.84 HTR2A (0.50) TSHRADRA2CL3MBTL1GAAPOLB
SCHEMBL30490050 0.84 SLC6A2 (0.46) TSHRADRA2CL3MBTL1GAAPKM
SCHEMBL18319286 0.84 HTR2A (0.50) TSHRADRA2CL3MBTL1LMNATDP1
SCHEMBL18319346 0.84 HTR2A (0.50) TSHRADRA2CL3MBTL1GAAPOLB
SCHEMBL30490055 0.84 ALDH1A1 (0.53) TSHRADRA2CL3MBTL1GAAPOLB
SCHEMBL30490051 0.84 HTR2A (0.50) TSHRADRA2CL3MBTL1LMNATDP1
SCHEMBL10870072 0.82 TSHR (0.62) TSHRADRA2CL3MBTL1GAAPKM
SCHEMBL18319287 0.81 MAOB (0.53) ADRA2CL3MBTL1GAALMNALTA4H
SCHEMBL18319356 0.80 CACNA1B (0.49) TSHRADRA2CL3MBTL1POLBLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2385037-A1 Fungicidal phenoxyphenylhydrazine derivatives Chemtura Corporation (US) 2011-11-09 EP claimed
JP-4331751-B2 2009-09-16 JP claimed
JP-2007518675-A 2007-07-12 JP claimed
US-7045512-B2 Fungicidal phenoxyphenylhydrazine derivatives UNIROYAL CHEMICAL COMPANY, INC. (US) 2006-05-16 US claimed
EP-1638923-A2 FUNGICIDAL PHENOXYPHENYLHYDRAZINE DERIVATIVES Uniroyal Chemical Company, Inc. (US) 2006-03-29 EP claimed
WO-2005005376-A2 FUNGICIDAL PHENOXYPHENYLHYDRAZINE DERIVATIVES UNIROYAL CHEMICAL COMPANY, INC. (US) 2005-01-20 WO claimed
US-20040266738-A1 Fungicidal phenoxyphenylhydrazine derivatives CROMPTON COLORS INCORPORATED 2004-12-30 US claimed
EP-0212753-B1 DIPHENYL ETHER HERBICIDES SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) 1990-05-30 EP claimed
EP-0212753-A1 Diphenyl ether Herbicides SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) 1987-03-04 EP claimed
JP-57028039-A None JP disclosed
CN-116283794-A 4-aminopyrimidine hydrazone compound containing diphenyl ether group and preparation method and application thereof 华中师范大学 2023-06-23 CN disclosed
US-9227917-B2 Amine-containing lipidoids and uses thereof MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 2016-01-05 US disclosed
EP-2385037-A1 Fungicidal phenoxyphenylhydrazine derivatives Chemtura Corporation (US) 2011-11-09 EP disclosed
EP-2385037-A1 Fungicidal phenoxyphenylhydrazine derivatives Chemtura Corporation (US) 2011-11-09 EP disclosed
EP-0212753-A1 Diphenyl ether Herbicides SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) 1987-03-04 EP disclosed
JP-S5728039-A PREPARATION OF DIPHENYL ETHER COMPOUND MITSUI TOATSU CHEM INC 1982-02-15 JP disclosed
US-4257952-A PSYCHOTROPIC DRUGS, ANALGESICS, ANTIHISTAMINES STERLING DRUG INC. (US) 1981-03-24 US disclosed
US-4172834-A ANALGESICS, ANTIHISTAMINES AND PSYCHOTROPIC AGENTS STERLING DRUG INC. (US) 1979-10-30 US disclosed
US-4062864-A ANALGESIC, PSYCHOTROPIC, ANTIHISTAMINE STERLING DRUG INC. (US) 1977-12-13 US disclosed
US-3959309-A ANALGESICS, PSYCHOTROPIC, ANTIHISTAMINE STERLING DRUG INC. (US) 1976-05-25 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040266738-A1 Fungicidal phenoxyphenylhydrazine derivatives CBR1, CBR3, CNPY2 TSHR 3272/4885ADRA2C 1193/4885L3MBTL1 231/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.