Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.45 |
| ▸ | FPR2 | P25090 | 7/20 | 0.44 |
| ▸ | FPR3 | P25089 | 3/20 | 0.44 |
| ▸ | RORC | P51449 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.41 |
| ▸ | STS | P08842 | 1/20 | 0.41 |
| ▸ | MMP1 | P03956 | 1/20 | 0.41 |
| ▸ | MMP3 | P08254 | 1/20 | 0.41 |
| ▸ | MMP7 | P09237 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15231313 | 0.93 | FPR2 (0.47) | FPR2FPR3ALDH1A1GPR119PTPN2 | |
| SCHEMBL20002917 | 0.88 | MEN1 (0.47) | ALDH1A1GPR119PDE4BPTPN2PTPN1 | |
| SCHEMBL14538368 | 0.81 | ALDH1A1 (0.48) | ALDH1A1GPR119PTPN2PTPN1PTPN6 | |
| SCHEMBL4773698 | 0.81 | MEN1 (0.51) | ALDH1A1GPR119PTPN2PTPN1PTPN6 | |
| SCHEMBL13229888 | 0.81 | STS (0.57) | ALDH1A1GPR119PTPN2PTPN1PTPN6 | |
| SCHEMBL13947677 | 0.80 | GPR119 (0.57) | USP30GPR119PTPN2PTPN1PTPN6 | |
| SCHEMBL22585176 | 0.78 | FPR2 (0.49) | FPR2FPR3GPR119PTPN2PTPN1 | |
| SCHEMBL17378585 | 0.78 | ALDH1A1 (0.60) | ALDH1A1GPR119PTPN2PTPN1PTPN6 | |
| SCHEMBL15232292 | 0.78 | GPR119 (0.58) | GPR119PTPN2PTPN1PTPN6 | |
| SCHEMBL19882905 | 0.76 | HPGD (0.47) | USP30ALDH1A1GPR119PTPN2PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3092229-B1 | PYRROLIDINYL SULFONE DERIVATIVES AND THEIR USE AS ROR GAMMA MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2018-03-28 | — | — | EP | disclosed |