Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 2/20 | 0.34 |
| ▸ | CHRM3 known ✓ | P20309 | 2/20 | 0.34 |
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 3/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | APEX1 | P27695 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | PGR | P06401 | 1/20 | 0.31 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.31 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.31 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.31 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.31 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.31 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18183740 | 0.98 | TSHR (0.47) | TSHRTHRBALDH1A1CHRM5CHRM1 | |
| Hydrochloric Acid SCHEMBL27806996 | 0.89 | TSHR (0.56) | TSHRTHRBALDH1A1POLBAPEX1 | |
| Hydrochloric Acid SCHEMBL29257672 | 0.88 | TSHR (0.59) | TSHRTHRBHTT | |
| SCHEMBL19992974 | 0.87 | TSHR (0.53) | TSHRTHRBALDH1A1HTTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL29257671 | 0.86 | TSHR (0.62) | TSHRTHRBHTT | |
| Hydrochloric Acid SCHEMBL28067877 | 0.86 | TSHR (0.62) | TSHRTHRBHTT | |
| Iodide SCHEMBL27848845 | 0.86 | TSHR (0.51) | TSHRTHRBALDH1A1HTTSMN1; SMN2 | |
| Fluoride Ion SCHEMBL27848852 | 0.86 | TSHR (0.51) | TSHRTHRBALDH1A1HTTSMN1; SMN2 | |
| Bromide SCHEMBL27827598 | 0.86 | TSHR (0.51) | TSHRTHRBALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL23530292 | 0.85 | TSHR (0.55) | TSHRTHRBALDH1A1CHRM5CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9932517-B1 | Polymer and preparation method thereof, and viscosified acid fluid | CHINA UNIVERSITY OF PETROLEUM (EAST CHINA) (CN) | 2018-04-03 | — | — | US | disclosed |