Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 17/20 | 0.52 |
| ▸ | RBP1 | P09455 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30266709 | 1.00 | TRPV4 (0.52) | TRPV4RBP1MEN1ALDH1A1TSHR | |
| SCHEMBL20003707 | 0.88 | TRPV4 (0.52) | TRPV4RBP1MEN1ALDH1A1TSHR | |
| SCHEMBL20003550 | 0.87 | TRPV4 (0.58) | TRPV4MEN1ALDH1A1TSHRKMT2A | |
| SCHEMBL20007988 | 0.87 | TRPV4 (0.58) | TRPV4MEN1ALDH1A1TSHRKMT2A | |
| SCHEMBL23613832 | 0.84 | TRPV4 (0.57) | TRPV4 | |
| SCHEMBL20007296 | 0.84 | TRPV4 (0.57) | TRPV4 | |
| SCHEMBL20003561 | 0.81 | TRPV4 (0.55) | TRPV4 | |
| SCHEMBL20007244 | 0.79 | TRPV4 (0.46) | TRPV4L3MBTL1PKM | |
| SCHEMBL23176162 | 0.78 | PKM (0.54) | TRPV4RBP1PKM | |
| SCHEMBL23613997 | 0.77 | TRPV4 (0.42) | TRPV4RBP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018055526-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2018-03-29 | — | — | WO | disclosed |