Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 4/20 | 0.46 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.41 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.41 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.41 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.41 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.41 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.41 |
| ▸ | PRCP | P42785 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | CXCR3 | P49682 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | PPARD | Q03181 | 1/20 | 0.36 |
| ▸ | CCR6 | P51684 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20007693 | 0.83 | TRPV4 (0.41) | TRPV4CXCR3POLB | |
| SCHEMBL23613990 | 0.83 | TRPV4 (0.41) | TRPV4CXCR3POLB | |
| SCHEMBL20007811 | 0.79 | TRPV4 (0.41) | TRPV4 | |
| SCHEMBL20007310 | 0.79 | TRPV4 (0.49) | TRPV4CCR6 | |
| SCHEMBL30266709 | 0.79 | TRPV4 (0.52) | TRPV4PKML3MBTL1 | |
| SCHEMBL20003548 | 0.79 | TRPV4 (0.52) | TRPV4PKML3MBTL1 | |
| SCHEMBL20007247 | 0.79 | TRPV4 (0.46) | TRPV4PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL20007703 | 0.77 | TRPV4 (0.43) | TRPV4GAA | |
| SCHEMBL20003707 | 0.77 | TRPV4 (0.52) | TRPV4L3MBTL1 | |
| SCHEMBL20007988 | 0.76 | TRPV4 (0.58) | TRPV4L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018055524-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2018-03-29 | — | — | WO | disclosed |