Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 16/20 | 0.60 |
| ▸ | AXL | P30530 | 7/20 | 0.60 |
| ▸ | KDR | P35968 | 7/20 | 0.60 |
| ▸ | MERTK | Q12866 | 3/20 | 0.57 |
| ▸ | RET | P07949 | 3/20 | 0.52 |
| ▸ | KIT | P10721 | 3/20 | 0.52 |
| ▸ | FLT3 | P36888 | 3/20 | 0.52 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.52 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.52 |
| ▸ | FLT1 | P17948 | 2/20 | 0.52 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.52 |
| ▸ | PLK4 | O00444 | 1/20 | 0.52 |
| ▸ | STK25 | O00506 | 1/20 | 0.52 |
| ▸ | CIT | O14578 | 1/20 | 0.52 |
| ▸ | AURKA | O14965 | 1/20 | 0.52 |
| ▸ | CHUK | O15111 | 1/20 | 0.52 |
| ▸ | MUSK | O15146 | 1/20 | 0.52 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.52 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.52 |
| ▸ | MAP3K13 | O43283 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20003724 | 0.91 | MET (0.60) | METAXLKDRMERTKRET | |
| SCHEMBL20003970 | 0.87 | MET (0.49) | METAXLKDRMERTKRET | |
| SCHEMBL18256865 | 0.86 | MET (0.65) | METAXLKDRMERTKRET | |
| SCHEMBL18256925 | 0.83 | MET (0.59) | METAXLKDRMERTKRET | |
| SCHEMBL19373358 | 0.81 | MET (0.88) | METAXLKDRMERTKRET | |
| SCHEMBL20003919 | 0.81 | MET (0.60) | METAXLKDRMERTKRET | |
| SCHEMBL18256959 | 0.81 | MET (0.67) | METAXLKDRMERTKRET | |
| SCHEMBL24444555 | 0.81 | MET (0.77) | METAXLKDRMERTKRET | |
| SCHEMBL20003858 | 0.80 | MET (0.62) | METAXLKDRMERTKRET | |
| SCHEMBL18256892 | 0.80 | AXL (0.79) | METAXLKDRMERTKRET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3299369-A1 | PYRIDO-AZAHETERECYDIC COMPOUND AND PREPARATION METHOD AND USE THEREOF | Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CN) | 2018-03-28 | — | — | EP | disclosed |