Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 9/20 | 0.47 |
| ▸ | OPRD1 | P41143 | 8/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 8/20 | 0.47 |
| ▸ | OPRL1 | P41146 | 5/20 | 0.47 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.40 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.40 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.40 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.40 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.40 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.39 |
| ▸ | SCD | O00767 | 1/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17465640 | 0.78 | OPRM1 (0.64) | OPRM1OPRD1OPRK1OPRL1HSD11B1 | |
| SCHEMBL12122918 | 0.70 | OPRM1 (0.63) | OPRM1OPRD1OPRK1OPRL1HSD11B1 | |
| SCHEMBL18701649 | 0.70 | SCD5 (0.53) | OPRM1OPRD1OPRK1OPRL1HSD11B1 | |
| SCHEMBL10819396 | 0.69 | OPRM1 (0.58) | OPRM1OPRD1OPRK1OPRL1HSD11B1 | |
| SCHEMBL13876257 | 0.69 | OPRM1 (0.59) | OPRM1OPRD1OPRK1OPRL1HSD11B1 | |
| SCHEMBL21077979 | 0.69 | OPRM1 (0.61) | OPRM1OPRD1OPRK1OPRL1HSD11B1 | |
| SCHEMBL11683633 | 0.68 | OPRM1 (0.56) | OPRM1OPRD1OPRK1OPRL1HSD11B1 | |
| SCHEMBL17220377 | 0.68 | SCD5 (0.57) | OPRM1OPRD1OPRK1OPRL1HSD11B1 | |
| SCHEMBL1513657 | 0.68 | TSHR (0.55) | OPRM1OPRD1OPRK1OPRL1HSD11B1 | |
| SCHEMBL18711613 | 0.67 | SCD5 (0.56) | OPRM1OPRD1OPRK1OPRL1HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180086757-A1 | TRIAZOLOPYRIDINE COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2018-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180086757-A1 | TRIAZOLOPYRIDINE COMPOUNDS AND METHODS OF USE THEREOF | JAK1, JAK2, JAK3 | OPRM1 697/4885OPRD1 709/4885OPRK1 283/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.