Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 3/20 | 0.43 |
| ▸ | DRD2 | P14416 | 6/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.39 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.38 |
| ▸ | CCR1 | P32246 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
| ▸ | HRH2 | P25021 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19998536 | 0.89 | MCHR1 (0.43) | P2RX7MCHR1OPRM1KCNH2 | |
| SCHEMBL20004196 | 0.81 | DRD2 (0.54) | P2RX7DRD2MCHR1SLC6A4SLC6A2 | |
| SCHEMBL17886625 | 0.77 | OPRM1 (0.48) | P2RX7DRD2OPRM1ALDH1A1CCR1 | |
| SCHEMBL17886622 | 0.76 | SLC6A4 (0.41) | DRD2SLC6A4SLC6A2SLC6A3OPRM1 | |
| SCHEMBL17886638 | 0.76 | DRD2 (0.46) | P2RX7DRD2SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL20004195 | 0.75 | OPRM1 (0.41) | P2RX7DRD2SLC6A4SLC6A3OPRM1 | |
| SCHEMBL16554044 | 0.75 | KCNH2 (0.40) | P2RX7DRD2SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL16553797 | 0.73 | EPHX2 (0.41) | P2RX7DRD2SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL12346684 | 0.73 | SLC6A3 (0.58) | SLC6A4SLC6A2SLC6A3OPRM1KCNH2 | |
| SCHEMBL8229096 | 0.73 | MEN1 (0.48) | SLC6A4ALDH1A1CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180086757-A1 | TRIAZOLOPYRIDINE COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2018-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180086757-A1 | TRIAZOLOPYRIDINE COMPOUNDS AND METHODS OF USE THEREOF | JAK1, JAK2, JAK3 | P2RX7 652/4885DRD2 1347/4885MCHR1 1784/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.