SCHEMBL20004400

SCHEMBL20004400

CC#CC(C)c1ccc(C(=O)N(C)CCF)cc1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC6 Q9UBN7 7/20 0.40
CYP1A2 P05177 1/20 0.37
CYP3A4 P08684 1/20 0.37
GAA P10253 1/20 0.37
CYP2D6 P10635 1/20 0.37
CYP2C9 P11712 1/20 0.37
CYP2C19 P33261 1/20 0.37
MLYCD O95822 2/20 0.36
ACACB O00763 1/20 0.36
HDAC3 O15379 2/20 0.36
HDAC1 Q13547 2/20 0.36
HDAC4 P56524 1/20 0.36
HDAC7 Q8WUI4 1/20 0.36
HDAC2 Q92769 1/20 0.36
HDAC10 Q969S8 1/20 0.36
HDAC11 Q96DB2 1/20 0.36
HDAC8 Q9BY41 1/20 0.36
HDAC9 Q9UKV0 1/20 0.36
HDAC5 Q9UQL6 1/20 0.36
MCHR1 Q99705 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20004334 0.82 HPGD (0.47) HDAC6CYP1A2CYP3A4GAACYP2D6
SCHEMBL22537874 0.74 CDK4 (0.49) HDAC6GAAMLYCDHDAC3HDAC1
SCHEMBL9873675 0.72 MLYCD (0.53) HDAC6MLYCDHDAC1ALDH1A1
SCHEMBL21115241 0.72 NSD2 (0.43) HDAC6CYP1A2CYP3A4GAACYP2D6
SCHEMBL22537607 0.71 ALDH1A1 (0.48) HDAC6CYP1A2CYP3A4GAACYP2D6
SCHEMBL24904581 0.70 HPGD (0.47) HDAC6CYP2D6CYP2C9MLYCDACACB
SCHEMBL21147043 0.69 ALDH1A1 (0.47) ALDH1A1
SCHEMBL24713185 0.68 HPGD (0.55) HDAC6CYP2C9HDAC1HDAC4MCHR1
SCHEMBL20715645 0.68 HPGD (0.51) HDAC6CYP2C9MLYCDACACBHDAC1
SCHEMBL23962422 0.66 HPGD (0.60) HDAC6GAACYP2C9HDAC3HDAC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2018055316-A1 COMPOUNDS FOR USING IN IMAGING AND PARTICULARLY FOR THE DIAGNOSIS OF NEURODEGENERATIVE DISEASES CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) 2018-03-29 WO disclosed