SCHEMBL20004631

SCHEMBL20004631

COc1cc(C)c(F)cc1C#Cc1ccc(C)cc1

nearest known ligand 0.40

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
AAK1 Q2M2I8 2/20 0.39
AR P10275 2/20 0.38
ACHE P22303 1/20 0.35
GRM5 P41594 2/20 0.35
CA12 O43570 3/20 0.35
CA2 P00918 3/20 0.35
CA9 Q16790 3/20 0.35
CA1 P00915 2/20 0.35
FFAR1 O14842 3/20 0.33
FFAR4 Q5NUL3 1/20 0.33
KCNH2 Q12809 1/20 0.33
ACACB O00763 1/20 0.33
TUBB1 Q9H4B7 2/20 0.33
ALDH1A1 P00352 1/20 0.33
CYP3A4 P08684 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20006752 0.86 AAK1 (0.44) AAK1ARACHEGRM5CA12
SCHEMBL28034740 0.85 AAK1 (0.45) AAK1ARACHEGRM5CA12
SCHEMBL20004846 0.82 FFAR1 (0.40) ACHEGRM5CA12CA2CA9
SCHEMBL31442895 0.78 ACHE (0.50) AAK1ARACHEGRM5CA12
SCHEMBL8979151 0.77 GRM5 (0.45) ACHEGRM5CA12CA2CA9
SCHEMBL19999378 0.76 APP (0.47) ACHECA12CA2CA9CA1
SCHEMBL10018714 0.76 GRM5 (0.44) ACHEGRM5CA12CA2CA9
SCHEMBL7857769 0.76 GRM5 (0.44) ACHEGRM5CA12CA2CA9
SCHEMBL7851710 0.76 FFAR1 (0.39) GRM5CA12CA2CA9CA1
SCHEMBL7858970 0.76 FFAR1 (0.39) GRM5CA12CA2CA9CA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3299439-A1 LIQUID CRYSTAL COMPOUND, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE JNC Corporation (JP) 2018-03-28 EP disclosed