SCHEMBL28034740

SCHEMBL28034740

COc1cc(C#Cc2ccc(C)cc2)c(OC)cc1C#Cc1ccc(C)cc1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AAK1 Q2M2I8 1/20 0.45
CA12 O43570 4/20 0.45
CA2 P00918 4/20 0.45
CA9 Q16790 4/20 0.45
AR P10275 4/20 0.45
CA1 P00915 3/20 0.45
KCNH2 Q12809 1/20 0.44
ACHE P22303 2/20 0.43
GRM5 P41594 1/20 0.42
ALDH1A1 P00352 1/20 0.39
CYP3A4 P08684 1/20 0.39
APP P05067 2/20 0.38
FFAR1 O14842 2/20 0.38
TUBB4A P04350 1/20 0.38
TUBB P07437 1/20 0.38
TUBA3C P0DPH7 1/20 0.38
TUBA1B P68363 1/20 0.38
TUBA4A P68366 1/20 0.38
TUBB4B P68371 1/20 0.38
TUBB3 Q13509 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31442895 0.89 ACHE (0.50) AAK1CA12CA2CA9AR
SCHEMBL20004631 0.85 AAK1 (0.39) AAK1CA12CA2CA9AR
SCHEMBL27878442 0.84 AR (0.49) AAK1CA12CA2CA9AR
SCHEMBL29120760 0.84 AAK1 (0.43) AAK1CA12CA2CA9AR
SCHEMBL20006752 0.84 AAK1 (0.44) AAK1CA12CA2CA9AR
SCHEMBL24819558 0.82 CA12 (0.37) CA12CA2CA9CA1KCNH2
SCHEMBL28034743 0.82 APP (0.60) CA12CA2CA9CA1ALDH1A1
SCHEMBL6005624 0.82 KCNH2 (0.50) AAK1CA12CA2CA9CA1
SCHEMBL9485072 0.81 RARB (0.45) AAK1CA12CA2CA9AR
SCHEMBL28352734 0.81 FFAR1 (0.56) AAK1CA12CA2CA9CA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-102718800-B 3,7-bis-(diphenyl phosphine oxygen base)-2,6-phenylbenzene benzo two furan derivatives, its preparation method and organic electroluminescence device Haiyangwang Lighting Technology Co., Ltd. (CN) 2015-10-28 CN disclosed