SCHEMBL20004813

SCHEMBL20004813

CCCCOc1ccc(-c2ccc(C#Cc3cc(F)c(C)cc3C)cc2)cc1

nearest known ligand 0.43

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
CYP2D6 P10635 7/20 0.43
CYP3A4 P08684 5/20 0.43
RARB P10826 4/20 0.43
RARA P10276 1/20 0.43
MCHR1 Q99705 1/20 0.42
CYP19A1 P11511 8/20 0.40
CYP2C9 P11712 8/20 0.40
CYP2C19 P33261 8/20 0.40
CYP1A2 P05177 5/20 0.40
ACACB O00763 2/20 0.40
KDM4E B2RXH2 2/20 0.37
ALDH1A1 P00352 2/20 0.37
HPGD P15428 2/20 0.37
HTT P42858 1/20 0.37
L3MBTL1 Q9Y468 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20005204 0.96 ACACB (0.42) CYP2D6CYP3A4RARBRARACYP19A1
SCHEMBL19999413 0.87 RARB (0.39) CYP2D6CYP3A4RARBRARAMCHR1
SCHEMBL20004894 0.83 RARA (0.39) CYP2D6CYP3A4RARBRARAMCHR1
SCHEMBL20005267 0.83 RARA (0.39) CYP2D6CYP3A4RARBRARAMCHR1
SCHEMBL19999450 0.82 S1PR1 (0.40) CYP2D6CYP3A4RARBRARAMCHR1
SCHEMBL19999369 0.82 CNR2 (0.40) CYP3A4ACACBALDH1A1
SCHEMBL20005277 0.81 NPC1 (0.35) CYP2D6RARBRARACYP19A1CYP2C9
SCHEMBL8775170 0.81 CYP2D6 (0.46) CYP2D6CYP3A4RARBRARAMCHR1
SCHEMBL19999499 0.80 RARB (0.39) CYP2D6CYP3A4RARBRARAMCHR1
SCHEMBL19999436 0.80 RARB (0.39) CYP2D6CYP3A4RARBRARAMCHR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3299439-A1 LIQUID CRYSTAL COMPOUND, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE JNC Corporation (JP) 2018-03-28 EP disclosed