SCHEMBL20005277

SCHEMBL20005277

CCCCOc1ccc(C2CC=C(c3ccc(C#Cc4cc(F)c(C)cc4C)cc3)C=C2F)cc1

nearest known ligand 0.35

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 1/20 0.35
CRBN Q96SW2 1/20 0.32
ACACB O00763 2/20 0.32
CYP1A2 P05177 1/20 0.31
CYP2D6 P10635 1/20 0.31
CYP19A1 P11511 1/20 0.31
CYP2C9 P11712 1/20 0.31
CYP2C19 P33261 1/20 0.31
RARA P10276 1/20 0.31
RARB P10826 1/20 0.31
MAOA P21397 1/20 0.30
MAOB P27338 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20004813 0.81 CYP2D6 (0.43) ACACBCYP1A2CYP2D6CYP19A1CYP2C9
SCHEMBL20005204 0.80 ACACB (0.42) ACACBCYP1A2CYP2D6CYP19A1CYP2C9
SCHEMBL19999413 0.72 RARB (0.39) ACACBCYP1A2CYP2D6CYP19A1CYP2C9
SCHEMBL19999369 0.70 CNR2 (0.40) ACACB
SCHEMBL21321662 0.69 S1PR3 (0.37) NPC1CRBNCYP1A2CYP2D6CYP19A1
SCHEMBL19999450 0.68 S1PR1 (0.40) ACACBCYP1A2CYP2D6CYP19A1CYP2C9
SCHEMBL20005267 0.67 RARA (0.39) NPC1ACACBCYP1A2CYP2D6CYP19A1
SCHEMBL20004894 0.67 RARA (0.39) NPC1ACACBCYP1A2CYP2D6CYP19A1
SCHEMBL19999411 0.67 ACACB (0.38) ACACBRARARARB
SCHEMBL19999436 0.67 RARB (0.39) ACACBCYP2D6RARARARB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3299439-A1 LIQUID CRYSTAL COMPOUND, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE JNC Corporation (JP) 2018-03-28 EP disclosed