SCHEMBL20005267

SCHEMBL20005267

CCCCOc1ccc(C#Cc2cc(F)c(-c3ccc4cc(-c5ccc(-c6ccc(C)cc6)cc5)ccc4c3)cc2C)cc1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RARA P10276 1/20 0.39
RARB P10826 1/20 0.39
MCL1 Q07820 1/20 0.38
CYP2D6 P10635 4/20 0.36
CYP3A4 P08684 3/20 0.36
MCHR1 Q99705 1/20 0.36
ACACB O00763 1/20 0.35
CHRNB2 P17787 1/20 0.35
CHRNB4 P30926 1/20 0.35
CHRNA3 P32297 1/20 0.35
CHRNA7 P36544 1/20 0.35
CHRNA4 P43681 1/20 0.35
FFAR4 Q5NUL3 2/20 0.34
FFAR1 O14842 1/20 0.34
ATP4A P20648 2/20 0.34
ATP4B P51164 2/20 0.34
CYP19A1 P11511 5/20 0.34
CYP2C9 P11712 5/20 0.34
CYP2C19 P33261 5/20 0.34
CYP1A2 P05177 3/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20004894 1.00 RARA (0.39) RARARARBMCL1CYP2D6CYP3A4
SCHEMBL19999499 0.91 RARB (0.39) RARARARBMCL1CYP2D6CYP3A4
SCHEMBL19999637 0.90 RARB (0.39) RARARARBMCL1CYP3A4ACACB
SCHEMBL20005210 0.88 ACACB (0.42) MCHR1ACACBFFAR4FFAR1MAPT
SCHEMBL19999411 0.87 ACACB (0.38) RARARARBMCL1CYP3A4ACACB
SCHEMBL20004878 0.85 HRH3 (0.38) RARARARBFFAR1HRH3
SCHEMBL20005285 0.84 FFAR1 (0.40) RARARARBFFAR1NPC1RAB9A
SCHEMBL20004879 0.84 FFAR1 (0.34) FFAR1CYP2C19CYP1A2MAPT
SCHEMBL20005287 0.83 ESR1 (0.38) FFAR1
SCHEMBL20004874 0.83 RARB (0.36) RARARARBCYP2D6CYP3A4MCHR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3299439-A1 LIQUID CRYSTAL COMPOUND, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE JNC Corporation (JP) 2018-03-28 EP disclosed