SCHEMBL20004874

SCHEMBL20004874

CCCCOc1cc(C)c(C#Cc2ccc(-c3ccc(-c4ccc(-c5ccc(C)cc5)cc4F)c(F)c3)cc2)cc1F

nearest known ligand 0.36

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
RARB P10826 2/20 0.36
RARA P10276 1/20 0.36
S1PR1 P21453 2/20 0.33
HRH3 Q9Y5N1 1/20 0.33
AAK1 Q2M2I8 1/20 0.33
KDM1A O60341 1/20 0.32
ACACB O00763 1/20 0.32
MCHR1 Q99705 1/20 0.31
CYP3A4 P08684 1/20 0.31
CYP2D6 P10635 1/20 0.31
PPARD Q03181 2/20 0.31
PPARA Q07869 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20005267 0.83 RARA (0.39) RARBRARAHRH3ACACBMCHR1
SCHEMBL20004894 0.83 RARA (0.39) RARBRARAHRH3ACACBMCHR1
SCHEMBL20004816 0.83 S1PR1 (0.36) RARBRARAS1PR1HRH3ACACB
SCHEMBL20005235 0.83 S1PR1 (0.36) RARBRARAS1PR1HRH3ACACB
SCHEMBL20005207 0.82 RARB (0.37) RARBRARAS1PR1AAK1ACACB
SCHEMBL19999533 0.80 FFAR1 (0.33) AAK1KDM1A
SCHEMBL20005210 0.79 ACACB (0.42) ACACBMCHR1
SCHEMBL19999436 0.78 RARB (0.39) RARBRARAS1PR1ACACBMCHR1
SCHEMBL19999450 0.78 S1PR1 (0.40) RARBRARAS1PR1ACACBMCHR1
SCHEMBL20004813 0.78 CYP2D6 (0.43) RARBRARAACACBMCHR1CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3299439-A1 LIQUID CRYSTAL COMPOUND, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE JNC Corporation (JP) 2018-03-28 EP disclosed