SCHEMBL20004893

SCHEMBL20004893

CCc1cc(-c2ccc(-c3ccc(C)cc3)cc2)cc(F)c1C#Cc1ccc(-c2cc(F)c(C)cc2F)cc1

nearest known ligand 0.34

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
PTGS2 P35354 2/20 0.34
PTGS1 P23219 1/20 0.33
PIK3CA P42336 1/20 0.31
MTOR P42345 1/20 0.31
KCNH2 Q12809 1/20 0.31
PDE3B Q13370 1/20 0.30
PDE3A Q14432 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20006716 0.89 FFAR1 (0.33)
SCHEMBL19999622 0.81 RARA (0.38)
SCHEMBL19999455 0.81 NPC1 (0.40)
SCHEMBL20005281 0.80 RARA (0.40)
SCHEMBL20006846 0.77 FFAR1 (0.38) KCNH2
SCHEMBL19999584 0.76 RARB (0.40) MTOR
SCHEMBL20004614 0.76 RARB (0.41)
SCHEMBL20005221 0.75 GRM5 (0.37) PTGS2KCNH2
SCHEMBL20004637 0.75 GRM5 (0.37) PTGS2KCNH2
SCHEMBL20005296 0.75 FFAR1 (0.35)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3299439-A1 LIQUID CRYSTAL COMPOUND, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE JNC Corporation (JP) 2018-03-28 EP disclosed