SCHEMBL20005281

SCHEMBL20005281

CCCOc1ccc(C#Cc2c(F)cc(-c3ccc(-c4ccc(C)cc4)cc3)cc2CC)cc1

nearest known ligand 0.40

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
RARA P10276 1/20 0.40
RARB P10826 1/20 0.40
MCHR1 Q99705 2/20 0.39
ACACB O00763 14/20 0.39
ACACA Q13085 2/20 0.38
ERN1 O75460 1/20 0.37
CHRM1 P11229 1/20 0.37
HTR2A P28223 1/20 0.37
MAOB P27338 1/20 0.37
MAPT P10636 1/20 0.36
THRB P10828 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19999622 0.94 RARA (0.38) RARARARBMCHR1ACACBACACA
SCHEMBL19999455 0.92 NPC1 (0.40) MCHR1ACACBERN1MAPT
SCHEMBL19999491 0.88 ACACB (0.47) RARARARBMCHR1ACACBACACA
SCHEMBL20004768 0.88 RARB (0.45) RARARARBMCHR1ACACBCHRM1
SCHEMBL20004622 0.88 MCHR1 (0.40) RARARARBMCHR1ACACBERN1
SCHEMBL20004614 0.85 RARB (0.41) RARARARBMCHR1ACACBACACA
SCHEMBL20004754 0.83 ACACB (0.40) RARARARBACACB
SCHEMBL20004797 0.81 S1PR1 (0.37) RARARARBACACBACACAMAOB
SCHEMBL20004893 0.80 PTGS2 (0.34)
SCHEMBL20005209 0.80 MCHR1 (0.36) RARARARBMCHR1ACACBACACA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3299439-A1 LIQUID CRYSTAL COMPOUND, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE JNC Corporation (JP) 2018-03-28 EP disclosed