Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | SLC18A3 | Q16572 | 2/20 | 0.41 |
| ▸ | LIPE | Q05469 | 2/20 | 0.40 |
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.40 |
| ▸ | PRCP | P42785 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22300290 | 0.78 | HRH3 (0.56) | HRH3KCNH2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL27675727 | 0.73 | KCNH2 (0.53) | HRH3KCNH2MAPTNPC1RAB9A | |
| SCHEMBL13588778 | 0.72 | KCNH2 (0.64) | HRH3KCNH2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL22537843 | 0.70 | HRH3 (0.55) | HRH3KCNH2MAPTNPC1RAB9A | |
| SCHEMBL19139666 | 0.70 | KCNH2 (0.42) | HRH3KCNH2MAPTNPC1RAB9A | |
| SCHEMBL20331351 | 0.70 | ALDH1A1 (0.44) | MAPTNPC1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL13182918 | 0.70 | NPC1 (0.59) | HRH3KCNH2MAPTNPC1RAB9A | |
| SCHEMBL13588795 | 0.70 | HRH3 (0.61) | HRH3KCNH2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL19703077 | 0.69 | ADAMTS5 (0.57) | HRH3KCNH2SMN1; SMN2LIPEADAMTS5 | |
| SCHEMBL4053721 | 0.67 | DRD2 (0.55) | SMN1; SMN2SLC18A3DRD2ALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3515912-B1 | COMPOUNDS FOR USING IN IMAGING AND PARTICULARLY FOR THE DIAGNOSIS OF NEURODEGENERATIVE DISEASES | CENTRE NAT RECH SCIENT (FR) | 2020-10-14 | — | — | EP | disclosed |
| WO-2018055316-A1 | COMPOUNDS FOR USING IN IMAGING AND PARTICULARLY FOR THE DIAGNOSIS OF NEURODEGENERATIVE DISEASES | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2018-03-29 | — | — | WO | disclosed |