SCHEMBL20005127

SCHEMBL20005127

Cc1c(I)n(S(=O)(=O)c2ccccc2)c2ncccc12

nearest known ligand 0.57

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
PTGDR2 Q9Y5Y4 10/20 0.57
MET P08581 1/20 0.46
CYP2C19 P33261 1/20 0.46
LATS1 O95835 1/20 0.43
HTR6 P50406 4/20 0.43
CCKAR P32238 1/20 0.42
SRC P12931 1/20 0.42
L3MBTL1 Q9Y468 1/20 0.40
SLC40A1 Q9NP59 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1778719 0.90 PTGDR2 (0.57) PTGDR2LATS1CCKARL3MBTL1
SCHEMBL1773016 0.86 PTGDR2 (0.67) PTGDR2CYP2C19LATS1HTR6CCKAR
SCHEMBL5136369 0.83 PTGDR2 (0.51) PTGDR2METCYP2C19LATS1HTR6
SCHEMBL4583577 0.83 PTGDR2 (0.64) PTGDR2METCYP2C19LATS1HTR6
Formamide SCHEMBL28651025 0.80 PTGDR2 (0.60) PTGDR2CYP2C19LATS1HTR6CCKAR
SCHEMBL19994702 0.79 MET (0.50) PTGDR2METCYP2C19HTR6L3MBTL1
SCHEMBL4583261 0.78 PTGDR2 (0.51) PTGDR2METCYP2C19LATS1HTR6
SCHEMBL15635129 0.78 PTGDR2 (0.64) PTGDR2CYP2C19LATS1HTR6CCKAR
SCHEMBL30539171 0.77 PTGDR2 (0.55) PTGDR2LATS1CCKARL3MBTL1
SCHEMBL17827487 0.75 PTGDR2 (0.63) PTGDR2CYP2C19LATS1HTR6CCKAR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10906900-B2 Compounds for using in imaging and particularly for the diagnosis of neurodegenerative diseases CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) 2021-02-02 US disclosed
US-10906900-B2 Compounds for using in imaging and particularly for the diagnosis of neurodegenerative diseases CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) 2021-02-02 US disclosed
EP-3515912-B1 COMPOUNDS FOR USING IN IMAGING AND PARTICULARLY FOR THE DIAGNOSIS OF NEURODEGENERATIVE DISEASES CENTRE NAT RECH SCIENT (FR) 2020-10-14 EP disclosed
EP-3515912-B1 COMPOUNDS FOR USING IN IMAGING AND PARTICULARLY FOR THE DIAGNOSIS OF NEURODEGENERATIVE DISEASES CENTRE NAT RECH SCIENT (FR) 2020-10-14 EP disclosed
US-20190211011-A1 COMPOUNDS FOR USING IN IMAGING AND PARTICULARLY FOR THE DIAGNOSIS OF NEURODEGENERATIVE DISEASES CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) 2019-07-11 US disclosed
US-20190211011-A1 COMPOUNDS FOR USING IN IMAGING AND PARTICULARLY FOR THE DIAGNOSIS OF NEURODEGENERATIVE DISEASES CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) 2019-07-11 US disclosed
WO-2018055316-A1 COMPOUNDS FOR USING IN IMAGING AND PARTICULARLY FOR THE DIAGNOSIS OF NEURODEGENERATIVE DISEASES CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) 2018-03-29 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10906900-B2 Compounds for using in imaging and particularly for the diagnosis of neurodegenerative diseases PSEN2, CLN6, MAPT PTGDR2 1114/4885MET 4720/4885CYP2C19 3826/4885
US-20190211011-A1 COMPOUNDS FOR USING IN IMAGING AND PARTICULARLY FOR THE DIAGNOSIS OF NEURODEGENERATIVE DISEASES PSEN2, SNCA, MAPT PTGDR2 1387/4885MET 4686/4885CYP2C19 4214/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.