Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 9/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | MET | P08581 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 5/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | LATS1 | O95835 | 1/20 | 0.39 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.39 |
| ▸ | CCKAR | P32238 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30539171 | 0.88 | PTGDR2 (0.55) | PTGDR2LATS1CCKAR | |
| SCHEMBL20005127 | 0.83 | PTGDR2 (0.57) | PTGDR2CYP2C19METHTR6SRC | |
| SCHEMBL15635129 | 0.83 | PTGDR2 (0.64) | PTGDR2CYP2C19HTR6LATS1CCKAR | |
| SCHEMBL30405250 | 0.80 | PTGDR2 (0.48) | PTGDR2CYP2C19METHTR6SRC | |
| SCHEMBL4583577 | 0.78 | PTGDR2 (0.64) | PTGDR2CYP2C19METHTR6LATS1 | |
| SCHEMBL4583261 | 0.78 | PTGDR2 (0.51) | PTGDR2CYP2C19METHTR6SRC | |
| SCHEMBL1267767 | 0.75 | CYP2C19 (0.56) | PTGDR2CYP2C19METHTR6SMN1; SMN2 | |
| SCHEMBL675512 | 0.75 | PTGDR2 (0.48) | PTGDR2CYP2C19METHTR6SRC | |
| SCHEMBL1773016 | 0.74 | PTGDR2 (0.67) | PTGDR2CYP2C19HTR6LATS1CCKAR | |
| SCHEMBL1049380 | 0.74 | HTR6 (0.55) | PTGDR2CYP2C19METHTR6SLC40A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1962830-A2 | AZAINDOLE INHIBITORS OF AURORA KINASES | SmithKline Beecham Corporation (US) | 2008-09-03 | — | — | EP | disclosed |
| WO-2007076348-A2 | AZAINDOLE INHIBITORS OF AURORA KINASES | SMITHKLINE BEECHAM CORPORATION (US) | 2007-07-05 | — | — | WO | disclosed |