Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 12/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | MET | P08581 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 2/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | LATS1 | O95835 | 1/20 | 0.39 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4583577 | 0.83 | PTGDR2 (0.64) | PTGDR2CYP2C19METHTR6LATS1 | |
| SCHEMBL20005127 | 0.78 | PTGDR2 (0.57) | PTGDR2CYP2C19METHTR6SRC | |
| SCHEMBL5136369 | 0.78 | PTGDR2 (0.51) | PTGDR2CYP2C19METHTR6SRC | |
| SCHEMBL1773016 | 0.74 | PTGDR2 (0.67) | PTGDR2CYP2C19HTR6LATS1 | |
| SCHEMBL5661951 | 0.74 | ENPP3 (0.44) | PTGDR2CYP2C19METPKMSRC | |
| SCHEMBL30751165 | 0.74 | ENPP3 (0.44) | PTGDR2CYP2C19METPKMSRC | |
| SCHEMBL1267767 | 0.72 | CYP2C19 (0.56) | PTGDR2CYP2C19METPKMHTR6 | |
| SCHEMBL15635129 | 0.72 | PTGDR2 (0.64) | PTGDR2CYP2C19HTR6LATS1 | |
| SCHEMBL31160484 | 0.72 | PTGDR2 (0.46) | PTGDR2CYP2C19LATS1 | |
| SCHEMBL1773438 | 0.71 | CYP2C19 (0.55) | PTGDR2CYP2C19METPKMSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1968568-A2 | INHIBITORS OF Akt ACTIVITY | SmithKline Beecham Corporation (US) | 2008-09-17 | — | — | EP | disclosed |
| WO-2007076423-A2 | INHIBITORS OF Akt ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2007-07-05 | — | — | WO | disclosed |
| WO-2007076423-A2 | INHIBITORS OF Akt ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2007-07-05 | — | — | WO | disclosed |