SCHEMBL20005218

SCHEMBL20005218

CCCCOc1cc(C)c(C#Cc2ccc(-c3ccc(-c4cc(F)c(F)c(F)c4)c(F)c3)c(F)c2)c(F)c1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RARA P10276 1/20 0.36
RARB P10826 1/20 0.36
MCL1 Q07820 1/20 0.35
S1PR1 P21453 2/20 0.35
S1PR3 Q99500 2/20 0.35
CYP2C9 P11712 6/20 0.33
CYP2C19 P33261 6/20 0.33
CYP19A1 P11511 5/20 0.33
CYP2D6 P10635 4/20 0.33
CYP1A2 P05177 4/20 0.33
CYP3A4 P08684 2/20 0.33
HMOX1 P09601 1/20 0.33
KDM4E B2RXH2 3/20 0.33
HPGD P15428 3/20 0.33
GAA P10253 1/20 0.33
ACACB O00763 1/20 0.32
ACACA Q13085 1/20 0.32
KAT6A Q92794 1/20 0.32
MAOB P27338 1/20 0.32
FFAR1 O14842 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18746541 0.82 S1PR1 (0.33) RARARARBS1PR1S1PR3
SCHEMBL18747299 0.81 S1PR1 (0.33) RARARARBS1PR1S1PR3FFAR1
SCHEMBL19999562 0.80 RARB (0.43) RARARARBMCL1ALDH1A1
SCHEMBL19999567 0.80 RARB (0.32) RARB
SCHEMBL19999404 0.80 RARB (0.38) RARARARB
SCHEMBL19999568 0.80 RARB (0.32) RARBL3MBTL1
SCHEMBL19999441 0.80 GRM5 (0.34) L3MBTL1
SCHEMBL20004548 0.80 DRD2 (0.40) KDM4EHPGDGAAACACBALDH1A1
SCHEMBL14887180 0.79 LTA4H (0.40) RARARARBACACBHTT
SCHEMBL19999465 0.79 TSHR (0.43) RARARARBALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3299439-A1 LIQUID CRYSTAL COMPOUND, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE JNC Corporation (JP) 2018-03-28 EP disclosed