Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 13/20 | 0.44 |
| ▸ | PKM | P14618 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20007659 | 0.86 | SPR (0.46) | TRPV4PKM | |
| SCHEMBL20007658 | 0.85 | TRPV4 (0.50) | TRPV4TRPM8KCNH2 | |
| SCHEMBL30266589 | 0.73 | TRPV4 (0.59) | TRPV4KCNH2 | |
| SCHEMBL21144237 | 0.73 | TRPV4 (0.59) | TRPV4KCNH2 | |
| SCHEMBL20007224 | 0.73 | TRPV4 (0.59) | TRPV4KCNH2 | |
| Hydrochloric Acid SCHEMBL28302865 | 0.67 | NPC1 (0.43) | SMN1; SMN2L3MBTL1 | |
| SCHEMBL19995428 | 0.67 | TRPV4 (0.79) | TRPV4KCNH2 | |
| SCHEMBL29355552 | 0.67 | TRPV4 (0.79) | TRPV4KCNH2 | |
| SCHEMBL23424526 | 0.67 | TRPV4 (0.63) | TRPV4TRPM8KCNH2 | |
| SCHEMBL29948946 | 0.67 | TRPV4 (0.63) | TRPV4TRPM8KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018055524-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2018-03-29 | — | — | WO | disclosed |