Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPR | P35270 | 1/20 | 0.46 |
| ▸ | TRPV4 | Q9HBA0 | 14/20 | 0.44 |
| ▸ | TDO2 | P48775 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | GPR183 | P32249 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20007658 | 0.88 | TRPV4 (0.50) | TRPV4 | |
| SCHEMBL20007225 | 0.86 | TRPV4 (0.44) | TRPV4PKM | |
| SCHEMBL23613973 | 0.71 | AR (0.33) | — | |
| SCHEMBL21144253 | 0.71 | TRPV4 (0.61) | TRPV4 | |
| SCHEMBL21144255 | 0.71 | TRPV4 (0.61) | TRPV4 | |
| SCHEMBL20007694 | 0.69 | CYP3A4 (0.53) | TRPV4TDO2HTR2AHTR2C | |
| SCHEMBL31554869 | 0.69 | SPR (0.43) | SPRTRPV4TDO2HTR2AHTR2C | |
| SCHEMBL20003557 | 0.67 | TRPV4 (0.59) | TRPV4 | |
| SCHEMBL20007296 | 0.67 | TRPV4 (0.57) | TRPV4 | |
| SCHEMBL23613832 | 0.67 | TRPV4 (0.57) | TRPV4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018055524-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2018-03-29 | — | — | WO | disclosed |