Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX3 | P56373 | 1/20 | 0.33 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.33 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23613867 | 0.73 | TRPV4 (0.37) | — | |
| SCHEMBL23613854 | 0.72 | TRPV4 (0.38) | SLC6A9 | |
| SCHEMBL23176333 | 0.72 | TRPV4 (0.38) | SLC6A9 | |
| SCHEMBL23176420 | 0.72 | CYP11B2 (0.35) | — | |
| SCHEMBL23613934 | 0.71 | TRPV4 (0.37) | — | |
| SCHEMBL20007251 | 0.71 | TRPV4 (0.42) | — | |
| SCHEMBL23614042 | 0.70 | TRPV4 (0.32) | SLC6A9TSHRSMN1; SMN2 | |
| SCHEMBL23613975 | 0.70 | TRPV4 (0.32) | SLC6A9 | |
| SCHEMBL23614029 | 0.68 | TRPV4 (0.32) | SLC6A9SMN1; SMN2 | |
| SCHEMBL23613886 | 0.64 | AR (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018055524-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2018-03-29 | — | — | WO | disclosed |