Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 12/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.36 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.36 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.36 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.36 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.36 |
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29352449 | 0.84 | TRPV4 (0.41) | TRPV4PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL21172026 | 0.84 | TRPV4 (0.41) | TRPV4PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL23613811 | 0.75 | TSHR (0.47) | TRPV4MEN1POLBKMT2AHSD11B1 | |
| SCHEMBL23613812 | 0.74 | KMT2A (0.38) | TRPV4KMT2APSEN1PSEN2APH1B | |
| SCHEMBL428472 | 0.74 | POLB (0.49) | TRPV4MEN1POLBKMT2A | |
| SCHEMBL28932757 | 0.73 | TRPV4 (0.42) | TRPV4PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL28932771 | 0.69 | TRPV4 (0.46) | TRPV4CYP3A4KCNH2 | |
| SCHEMBL30266529 | 0.69 | TRPV4 (0.63) | TRPV4CYP3A4KCNH2 | |
| SCHEMBL31453522 | 0.69 | PKM (0.51) | MEN1POLBKMT2A | |
| SCHEMBL28422650 | 0.69 | MEN1 (0.36) | TRPV4MEN1POLBKMT2APSEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018055524-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2018-03-29 | — | — | WO | disclosed |