Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.37 |
| ▸ | DRD2 | P14416 | 2/20 | 0.37 |
| ▸ | DRD4 | P21917 | 2/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.37 |
| ▸ | DRD3 | P35462 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.35 |
| ▸ | KCNA3 | P22001 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14101146 | 0.77 | TSHR (0.42) | TSHRCYP1A2ATMCYP2D6DRD2 | |
| SCHEMBL8362586 | 0.76 | TSHR (0.52) | TSHRCYP1A2ATMCYP2D6MEN1 | |
| SCHEMBL639889 | 0.75 | ATM (0.41) | TSHRCYP1A2ATMCYP2D6DRD2 | |
| SCHEMBL8755619 | 0.75 | ALDH1A1 (0.41) | TSHRCYP1A2ATMCYP2D6DRD2 | |
| SCHEMBL11143559 | 0.75 | TSHR (0.50) | TSHRCYP1A2ATMCYP2D6DRD2 | |
| SCHEMBL6846624 | 0.75 | ATM (0.41) | TSHRCYP1A2ATMCYP2D6DRD2 | |
| SCHEMBL5152927 | 0.75 | TSHR (0.50) | TSHRCYP1A2ATMCYP2D6DRD2 | |
| SCHEMBL28857197 | 0.73 | ALDH1A1 (0.40) | TSHRCYP1A2ATMCYP2D6DRD2 | |
| SCHEMBL10486722 | 0.73 | TSHR (0.37) | TSHRCYP1A2ATMCYP2D6DRD2 | |
| SCHEMBL7030622 | 0.72 | MAPK1 (0.46) | TSHRATMCYP2D6DRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 66 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599584-A1 | MODIFIED NITRILASES AND THEIR USE IN METHODS FOR THE PRODUCTION OF CARBOXYLIC ACIDS | BASF AKTIENGESELLSCHAFT (DE) | 2005-11-30 | — | — | EP | claimed |
| WO-2004076655-A1 | MODIFIED NITRILASES AND THEIR USE IN METHODS FOR THE PRODUCTION OF CARBOXYLIC ACIDS | BASF AKTIENGESELLSCHAFT (DE) | 2004-09-10 | — | — | WO | claimed |
| EP-0527553-B1 | Process for producing r(-)-mandelic acid and derivative thereof | NITTO CHEMICAL INDUSTRY CO LTD (JP) | 1997-05-07 | — | — | EP | claimed |
| US-5296373-A | Stereoselective hydrolysis of mandelonitrile in neutral or basic aqueous medium | NITTO CHEMICAL INDUSTRY CO., LTD. (JP) | 1994-03-22 | — | — | US | claimed |
| EP-0527553-A1 | Process for producing r(-)-mandelic acid and derivative thereof | NITTO CHEMICAL INDUSTRY CO., LTD. (JP) | 1993-02-17 | — | — | EP | claimed |
| US-9828594-B2 | Nitrilases, nucleic acids encoding them and methods for making and using them | BASF ENZYMES LLC (US) | 2017-11-28 | — | — | US | disclosed |
| US-20160355801-A1 | NITRILASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM | VERENIUM CORPORATION | 2016-12-08 | — | — | US | disclosed |
| US-9315792-B2 | Nitrilases, nucleic acids encoding them and methods for making and using them | BASF ENZYMES LLC (US) | 2016-04-19 | — | — | US | disclosed |
| US-9217164-B2 | Nitrilases, nucleic acids encoding them and methods for making and using them | BASF ENZYMES LLC (US) | 2015-12-22 | — | — | US | disclosed |
| EP-2327766-B1 | Nitrilases | BASF ENZYMES LLC (US) | 2015-12-02 | — | — | EP | disclosed |
| EP-2319919-B1 | Nitrilases | BASF ENZYMES LLC (US) | 2015-08-12 | — | — | EP | disclosed |
| EP-1576108-B1 | NITRILASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM | BASF ENZYMES LLC (US) | 2015-07-08 | — | — | EP | disclosed |
| WO-2003097810-A2 | NITRILASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM | DIVERSA CORPORATION (US) | 2003-11-27 | — | — | WO | disclosed |
| WO-2003098187-A2 | ASSAYS AND KITS FOR DETECTING THE PRESENCE OF NITRILES AND/OR CYANIDE | DIVERSA CORPORATION (US) | 2003-11-27 | — | — | WO | disclosed |
| US-20030124698-A1 | Which stereoselectively hydrolyze nitrites or cyanohydrins into acids and ammonia | DIVERSA CORPORATION | 2003-07-03 | — | — | US | disclosed |
| WO-2003000840-A2 | NITRILASES | DIVERSA CORPORATION (US) | 2003-01-03 | — | — | WO | disclosed |
| EP-0527553-B1 | Process for producing r(-)-mandelic acid and derivative thereof | NITTO CHEMICAL INDUSTRY CO LTD (JP) | 1997-05-07 | — | — | EP | disclosed |
| CN-1033142-C | A process for preparing pharmaceutical composition showing properties in against human immunodeficiency virus | JANSSEN PHARMACEUTICA NV (BE) | 1996-10-30 | — | — | CN | disclosed |
| US-5296373-A | Stereoselective hydrolysis of mandelonitrile in neutral or basic aqueous medium | NITTO CHEMICAL INDUSTRY CO., LTD. (JP) | 1994-03-22 | — | — | US | disclosed |
| EP-0527553-A1 | Process for producing r(-)-mandelic acid and derivative thereof | NITTO CHEMICAL INDUSTRY CO., LTD. (JP) | 1993-02-17 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030124698-A1 | Which stereoselectively hydrolyze nitrites or cyanohydrins into acids and ammonia | NIT2, DNPH1, ASNS | TSHR 4562/4885CYP1A2 1283/4885ATM 3153/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.