Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.39 |
| ▸ | DRD2 | P14416 | 2/20 | 0.39 |
| ▸ | DRD4 | P21917 | 2/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.39 |
| ▸ | DRD3 | P35462 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | SCN1A | P35498 | 1/20 | 0.38 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.38 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL639889 | 0.79 | ATM (0.41) | ATMCYP2D6DRD2DRD4OPRM1 | |
| SCHEMBL8755619 | 0.79 | ALDH1A1 (0.41) | ATMCYP2D6DRD2DRD4OPRM1 | |
| SCHEMBL28857197 | 0.77 | ALDH1A1 (0.40) | ATMCYP2D6DRD2DRD4OPRM1 | |
| SCHEMBL16428437 | 0.75 | TSHR (0.46) | ATMCYP2D6DRD2DRD4OPRM1 | |
| SCHEMBL200076 | 0.75 | TSHR (0.46) | ATMCYP2D6DRD2DRD4OPRM1 | |
| SCHEMBL200565 | 0.75 | ALDH1A1 (0.43) | ATMCYP2D6DRD2DRD4OPRM1 | |
| SCHEMBL27390196 | 0.75 | ALDH1A1 (0.43) | ATMCYP2D6DRD2DRD4OPRM1 | |
| SCHEMBL3995663 | 0.75 | ALDH1A1 (0.43) | ATMCYP2D6DRD2DRD4OPRM1 | |
| SCHEMBL1444134 | 0.75 | ATM (0.45) | ATMCYP2D6DRD2DRD4OPRM1 | |
| SCHEMBL18133808 | 0.74 | TSHR (0.43) | ATMCYP1A2CYP2C9CYP2C19TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040087583-A1 | Amino-thio-acrylonitriles as MEK inhibitors | HOBBS FRANK WORDEN (US) | 2004-05-06 | — | — | US | disclosed |
| US-6703420-B1 | MITOGEN ACTIVATED PROTEIN KINASE (MAPK) INHIBITORS; ANTIINFLAMMATORY, ANTICARCINOGENIC, OR ANTIPROLIFERATIVE AGENTS; RADIOSENSITIZERS | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2004-03-09 | — | — | US | disclosed |
| US-20020058699-A1 | Methods for treating seizure disorders by inhibiting MAPK pathway activation | BAYLOR COLLEGE OF MEDICINE | 2002-05-16 | — | — | US | disclosed |
| WO-2002002097-A2 | METHODS FOR TREATING SEIZURE DISORDERS BY INHIBITING MAPK PATHWAY ACTIVATION WITH NITRILES | SWEATT J DAVID (US) | 2002-01-10 | — | — | WO | disclosed |
| EP-1163215-A1 | AMINO-THIO-ACRYLONITRILES AS MEK INHIBITORS | Du Pont Pharmaceuticals Company (US) | 2001-12-19 | — | — | EP | disclosed |
| WO-2000056706-A1 | AMINO-THIO-ACRYLONITRILES AS MEK INHIBITORS | DU PONT PHARMACEUTICALS COMPANY (US) | 2000-09-28 | — | — | WO | disclosed |
| US-4698333-A | Use of substituted malonic acid derivatives as agents for combating pests | BAYER AKTIENGESELLSCHAFT (DE) | 1987-10-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020058699-A1 | Methods for treating seizure disorders by inhibiting MAPK pathway activation | MAPKAPK2, MAPK1, MAPK4 | ATM 1153/4885CYP2D6 4083/4885DRD2 2800/4885 |
| US-20040087583-A1 | Amino-thio-acrylonitriles as MEK inhibitors | MAPK1, MAP3K1, CDKN1A | ATM 10/4885CYP2D6 1227/4885DRD2 4606/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.