Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | RBP1 | P09455 | 1/20 | 0.44 |
| ▸ | PKLR | P30613 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | CCR1 | P32246 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23613871 | 0.80 | TRPV4 (0.60) | RBP1TRPV4 | |
| SCHEMBL20003616 | 0.80 | TRPV4 (0.60) | RBP1TRPV4 | |
| SCHEMBL20003518 | 0.80 | TRPV4 (0.60) | RBP1TRPV4 | |
| SCHEMBL20003572 | 0.78 | TRPV4 (0.50) | KMT2ARBP1CCR1PKMMEN1 | |
| SCHEMBL23613838 | 0.78 | TRPV4 (0.50) | LMNARBP1GAAALDH1A1HTT | |
| SCHEMBL20003562 | 0.78 | TRPV4 (0.51) | LMNARBP1GAAALDH1A1CCR1 | |
| SCHEMBL20007697 | 0.76 | TRPV4 (0.52) | RBP1ALDH1A1KDM4EPKMTRPV4 | |
| SCHEMBL20007988 | 0.75 | TRPV4 (0.58) | TSHRKMT2AALDH1A1MEN1TRPV4 | |
| SCHEMBL20003513 | 0.75 | TRPV4 (0.61) | TRPV4 | |
| SCHEMBL20003510 | 0.75 | TRPV4 (0.61) | TRPV4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018055524-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2018-03-29 | — | — | WO | disclosed |