Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 7/20 | 0.52 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | RBP1 | P09455 | 1/20 | 0.43 |
| ▸ | GPR183 | P32249 | 1/20 | 0.43 |
| ▸ | CTDSP1 | Q9GZU7 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20003557 | 0.83 | TRPV4 (0.59) | TRPV4 | |
| SCHEMBL20007774 | 0.81 | TRPV4 (0.55) | TRPV4NR3C1KDM4EALDH1A1RBP1 | |
| SCHEMBL23613832 | 0.81 | TRPV4 (0.57) | TRPV4 | |
| SCHEMBL20007296 | 0.81 | TRPV4 (0.57) | TRPV4 | |
| SCHEMBL19158885 | 0.80 | PKM (0.54) | TRPV4NR3C1PKMKDM4EATM | |
| SCHEMBL20003515 | 0.76 | TRPV4 (0.52) | TRPV4RBP1 | |
| SCHEMBL20003513 | 0.76 | TRPV4 (0.61) | TRPV4 | |
| SCHEMBL23176371 | 0.76 | TRPV4 (0.55) | TRPV4 | |
| SCHEMBL20003561 | 0.76 | TRPV4 (0.55) | TRPV4 | |
| SCHEMBL23614016 | 0.76 | TRPV4 (0.55) | TRPV4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3515888-B1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE IP NO 2 LTD (GB) | 2021-03-31 | — | — | EP | disclosed |
| WO-2018055524-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2018-03-29 | — | — | WO | disclosed |